19, 0.80-1.78) was not.
Conclusions: Younger (<40y) HCV LT recipients have significantly reduced graft survival, higher rates of re-LT and HCV-related death than older HCV recipients. This suggests a more aggressive natural history for HCV disease post-LT and identifies a group in need of early consideration of HCV therapy. Disclosures: Norah Terrault - Advisory Committees or Review Panels: Eisai, Biotest; Consulting: BMS, Merck; Grant/Research Support: Eisai, Biotest, Vertex, Gilead, AbbVie, Novartis, Merck The following people have nothing to disclose: Varun Saxena, Jennifer L. Dodge, John P. Roberts Background/Aims: To identify the impact of portal vein thrombosis (PVT) on post liver transplant Selleck Birinapant (LT) outcomes along with other covariates and assess factors associated with complications amongst PVT patients. Methods: Fer-1 in vitro Retrospective cohort study of 621 adult LT recipients (University of Alberta, London Health Sciences Centre) between 01/2002-12/2012. PVT
was identified in 147 (24%) patients and 474 (76%) non-PVT patients served as controls. Cox survival analysis was performed to determine independent associations with overall mortality. Results: Demographic factors (mean age 53, 69% male) were similar between groups. There were also no differences in mean MELD (PVT 19 vs. controls 19, p=0.9) and Child Pugh scores (10 vs. 10, p=0.9) on the day of LT. Donor factors (mean DRI:1.6 vs. 1.5, p=0.2) were similar. Using Cox multivariable survival analysis, covariates independently associated with overall mortality included Age (adjusted Hazard ratio ∼ aHR 1.02, p=0.015) and requiring ICU support pre-LT (aHR 2.17, p=0.006), but not PVT (p=0.67). 5-year survival was similar between PVT and controls (75%,p= 0.8). In comparing PVT patients who did not survive (n=32) with PVT survivors (n=115), non-survivors (n=32) were more likely to have complete thrombus occlusion (38% vs. 13%, p=0.027) and
hepatofugal flow (31% vs. 13%, p=0.08). Non-survivors were more likely require thrombectomy (69 vs. 31%, p=0.08) and develop reocclusion post-LT (16% vs. 3%, p=0.024). Anti-coagulation rates were similar between groups. Conclusion: Well-selected LT patients who had PVT prior to LT have similar post-LT outcomes with Ketotifen controls when adjusting for donor and recipient factors. Subgroups of PVT LT patients who did worse post-LT (complete thrombosis pre-LT, thrombectomy at LT and reocclusion post-LT) warrant closer evaluation in listing and management post-LT. Adjusted survival (Cox) for PVT LT recipients vs. controls (p=0.67). Disclosures: Constantine J. Karvellas – Grant/Research Support: Merck; Speaking and Teaching: Gambro The following people have nothing to disclose: Filipe S. Cardoso, Malcolm M. Wells, Fayaz A. Handoo, Lukasz Kwapisz, Mansour G. Alghanem, Norman Kneteman, Paul Marotta, Bandar Al-Judaibi Background.