Females had a higher. Key Word(s): 1. COLITE; 2. COLITE ISQUEMICA; 3. ACHADOS; 4. RESULDADOS; Presenting Author: MAKKIHUMMADI FAYADH Corresponding Author: MAKKIHUMMADI FAYADH Affiliations: Advanced Center for Day Care Surgery Objective: Cowden syndrome (CS) or disease (CD) is an autosomal-dominant disorder associated with multiple hamartomatous and neoplastic lesions of the skin, mucous membranes, thyroid, breast, colon, endometrium and brain, The incidence is 1/200.000 Case presentation- A local 27 years old Emirati male patient

presented with abdominal pain with multiple subcutaneous lesions with previous operations for thyroid nodules &multiple subcutaneous

nodules. Clinical examination showed multiple trichilemmomas MI-503 in the face, pigmentation in the thigh and genitalia with multiple subcutaneous nodules. Upper endoscopy showed multiple esophageal glycogen acanthotic lesions with multiple small gastric and duodenal polyps. Colonoscopy showed multiple small polyps, The biopsy showed esophageal acanthosis, hyperplastic & hamartomatous polyposis of stomach, duodenum and colon, Video capsule study showed multiple jejunal and ileal polyps Family history of colon cancer, thyroid disease, pancreatic cancer, breast lumps Genetic test for the TPEN gene was positive MRI brain showed A-V mal

click here formation in the posterior cerebral circulation This is the first case of Cowden disease described in UAE to our knowledge A plan for his family screening will be started. A detailed description of the case and review of Cowden disease is presented Colleagues are asked to look for this disease in any patient who has glycogen acanthosis associasted with polyposis as we feel that this disease is under diagnosed in our area Methods: case study of skin lesions associated with gastrointestinal polyposis and positive family history of cancers. Results: awareness of the disease is important for the fami Colleagues are asked to look for this disease in any patient who has glycogen acanthosis associasted with polyposis 上海皓元 as we feel that this disease is under diagnosed in our arealy Conclusion: Cowden syndrome (CS) or disease (CD) is an autosomal-dominant disorder associated with multiple hamartomatous and neoplastic lesions of the skin, mucous membranes, thyroid, breast, colon, endometrium and brain, The incidence is 1/200.000 awareness for doctors including dental, skin disease specialists, ent, surgeons, endoscrinologists, endoscopists is needed not to miss similare cases. Key Word(s): 1. Cowden’s disease; 2. GITpolyposis; 3.

Results: From 1127 selleck screening library patients we found that Helicobacter pylori positive from histopathology

were 134 patient and 993 patients were negative for Helicobacter (11.8%). The proportion of male was 55.3% and female was 44.7%. Mean age from patients was 47 years old. Mean age for metaplasia patients was 55 years old, dysplasia patients was 73 years old and malignant patients was 64 years old. From this study we found metaplasia from 45 patients, dysplasia 4 patients and 7 patients has gastric malignancy. Metaplasia was found 33 from 955 (3, 3%) who were negative for H. pylori and 12 patients from 116 (9, 2%) who were positive for H. pylori. From seven patients with gastric malignancy were positive for Helicobacter infection. Conclusion: From this study we found that a Helicobacter pylori infection was associated with metaplasia intestinal and gastric malignancy.

Key Word(s): 1. H. pylori infection; 2. Jakarta; 3. gastric metaplasia; 4. gastric malignancy; Presenting Author: NIAN FANG Additional Authors: HUIQING ZHANG, NIXIAO HAN, GEN HUANG, LINGZI FANG, NONGRONG WANG, KUNHE ZHANG Corresponding Author: NIAN FANG Affiliations: selleck chemicals university Objective: To observe the effects of AFP gene silencing by siRNA on Survivin mRNA of hepatocellular carcinoma cell line HepG2. Methods: AFP gene expression was downregulated in HepG2 cell by RNAi, and the AFP content in supernatant was detected by ELISA, Survivin mRNA level was tested by RT-PCR. MTT was applied to evaluated cell proliferation, and flow cytometry was employed MCE to observe cell apoptosis. Results: At the time of 48 hours after transfection, AFP expression was almost completely inhibited, cell proliferation activity was decreased 43.1%, cell apoptosis rate was increased

24.3%, and the Survivin mRNA expression was reduced to 22.0% in the experimental group, but no obvious changes were observed in the negative control and blank groups. Conclusion: AFP gene silenced by RNAi induces growth inhibition and apoptosis promotion of hepatocellular carcinoma cell line HepG2, and it maybe associated with the suppression of Survivin mRNA. Key Word(s): 1. HCC; 2. AFP; 3. Survivin; 4. RNA interference; Presenting Author: PING HAN Additional Authors: WEI YAN, DEAN TIAN Corresponding Author: PING HAN, WEI YAN, DEAN TIAN Affiliations: Tongji Medical College Objective: Epithelial-mesenchymal transition (EMT) is a critical step in the metastatic progression of epithelial carcinomas, Blood vessel epicardial substance (BVES) was found to prevent migration and invasion in some solid cancers, however, the role it plays in human hepatocellular carcinoma (HCC) has never been detailed researched. Netrin-1 is a secreted, laminin-related protein which was discovered to promote EMT of HCC in our previous research. In this study, we aimed to exam the role of BVES in HCC, and investigate the upstream factor Netrin-1 role in regulating the expression of BVES.

001 < P < 0.01 (denoted by **) corresponds to very significant, 0.01 < P < 0.05 (denoted by *) corresponds to significant, and P > 0.05 is not significant (ns). The overall sensitivity of anti-E1E2 antibodies for the prediction of treatment response was calculated using receiver operating characteristic (ROC) curves in one-point studies HM781-36B nmr and at different time points before and during treatment in follow-up studies. Optimal cutoff values were defined using the highest sum of sensitivity and specificity. For each optimal cutoff value, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Five negative controls (NHS) were initially tested at different dilutions:

1/50, 1/100, 1/250, 1/500, and 1/1000 (Fig. 1A). Standard dilutions selected were 1/250 and 1/500. The cutoff values for both dilutions were determined with 17 NHS (negative Linsitinib concentration for HCV, HBV, and HIV; Fig. 1B). The mean OD values for E1, E2A, and E2B were 0.609 ± 0.033 for 1/250 dilution and 0.374 ± 0.036 for 1/500 dilution. The cutoff was calculated as the mean value + 3 SD, and corresponded to 0.708 for the 1/250 dilution and 0.482 for the 1/500 dilution. Each serum sample was tested in triplicate for the E1, E2A, and E2B peptides. For an easier representation of results, they were expressed as the average of OD obtained for E1, E2A,

and E2B, which are very similar (Fig. 1B). The interpretation for the presence or absence of anti-E1E2A,B antibodies took place according to these mean OD values. If the mean value was greater than or equal to the cutoff for a fixed dilution, the sample was defined as positive or the limit for this dilution.

If it was under the cutoff, the sample was considered negative. All the sera positive for anti-E1E2A,B contain antibodies that bind to the D32.10 epitope, i.e., to the three peptides, E1, E2A, and E2B. Inversely, the negative sera do not contain any of them. Therefore, these antibodies are called “D32.10 epitope-binding antibodies” throughout the text. At least five NHS were systematically included in each assay, and the medchemexpress cutoff was recalculated for each type of experiments. The intra-assay variability was evaluated by testing a same positive sample 10 times in an intra-assay run, and showed a coefficient of variation < 4%. The inter-assay variability was evaluated by testing a same positive sample in triplicate in seven independent runs at different days by the same technician, and showed a coefficient of variation < 5%. Figure 2A shows the results obtained with samples from 52 patients cured of HCV infection (Group 1: C). Twenty-two patients who had spontaneously cleared a past infection (≥10 years) corresponded to the series 1, whereas the 30 other patients whose date of acute infection was unknown corresponded to the series 2. Among the total of 52 C patients, 46 were found positive for anti-E1E2A,B antibodies (88.5%) with a higher prevalence (21 of 22, 95.5%) in the series 1.

However, once chronic infection is established, the –443TT genotype of the OPN promoter region and the –1195GG genotype of the COX-2 promoter are thought to promote inflammation and contribute to the progression of liver disease.

“
“The liver is the major organ for the metabolism of protein, fat and carbohydrate. A nutritional approach is required in the treatment of cirrhosis, which is frequently complicated with protein–energy malnutrition. Several advanced treatment approaches for hepatocellular carcinoma (HCC) have been established in the past decade. HCC is often complicated by cirrhosis, so treatment AZD6738 purchase of the underlying liver diseases is also necessary to improve the prognosis. Branched-chain amino acid (BCAA) granules were developed originally for the treatment

of hypoalbuminemia associated with decompensated cirrhosis. However, subsequent studies found various other pharmacological actions of this agent. We review the clinical significance of therapy using BCAA granules in patients receiving different treatment approaches for cirrhosis and HCC based on the published work as well as our own data. THE LIVER IS the major organ for the metabolism of protein, fat and carbohydrate.[1, 2] Cirrhosis, which develops over a long period of time, is frequently complicated with protein–energy malnutrition (PEM).[1, 2] Patients with cirrhosis-associated PEM starve even after a short period of fasting because of the increased energy consumption and decreased glycogen-storage capacity of the liver. The body consumes the endogenous fat Selumetinib manufacturer as an energy

substrate instead of carbohydrate. As a result, fasting hypoglycemia and postprandial hyperglycemia typically occur.[1-4] PEM affects the prognosis by increasing the risk of cirrhosis-associated events and deteriorating the patient’s quality of life (QoL), so nutritional treatment is absolutely crucial.[1-3] The treatment MCE of hepatocellular carcinoma (HCC) has improved appreciably in the past 20–30 years. The current treatment for HCC with established efficacy is: (i) hepatectomy/liver transplantation; (ii) transcatheter arterial chemoembolization (TACE); (iii) percutaneous radiofrequency ablation (RFA); (iv) percutaneous ethanol injection; (v) percutaneous microwave coagulation therapy; and (vi) molecular-targeted therapy (e.g. sorafenib).[5-9] The most suitable treatment should be selected for individual patients based on thorough evaluation of HCC stage (tumor factor) and hepatic functional reserve.[5-10] In general, HCC develops after cirrhosis associated with viral hepatitis or alcoholic liver disease, so treatment of the underlying liver diseases is no less important than HCC treatment.[5-9, 11] Preserving adequate hepatic reserves is necessary after HCC recurrence, which is quite frequent no matter how successful the initial radical treatment for HCC.

143,144 However, definitions of clinical relapse and measurements of disease severity vary between studies. In studies from across Asia, most patients with UC had a milder disease course,35,70 with more frequent relapsing

disease course rather than continuous active disease.56,80 A study from South Korea reported cumulative relapse rates after 1, 5, and 10 years to be 30%, 72%, and 88%, respectively.84 In a Malaysian study, no significant differences were seen in the severity of disease between different IBD patients of different ethnicities.56 A recent study from Korea found that for patients diagnosed at age 40 years or less disease was more severe at presentation than those diagnosed at age greater than 40 years. Cumulative relapse ZD1839 and surgical rates were not different.145 In a separate Korean study146

comparing 39 patients aged 18–44, to 34 patients aged 45–85, age less than 45 was found to be an independent predictor of relapse in UC, similar to data from a previous Western study.147 Colectomy.  Studies from the West have reported cumulative colectomy rates at one year of 6–11%, 5 years of 20% and 10 years of 24–28%.90,143,148 Colectomy rates are lower in Asian BAY 57-1293 in vivo UC patients, with rates at one year 2.0–4.1%;84,149 5 years, 5.9%;56 and 10 years, 7.6–15.6%.26,56 It is unclear whether these lower colectomy rates are related to a milder disease presentation and course in Asian subjects, variations in disease management in Asia, or different physician and patient thresholds for colectomy. A recent Japanese study identified early factors predicting colectomy in patients who did not undergo colectomy within their first month of diagnosis. These included moderate or severe disease at diagnosis, as assessed using Truelove and Witt criteria, as well as low hemoglobin and albumin 4 weeks after first induction therapy.138 Colorectal cancer.  Colorectal cancer (CRC) is a known complication of long term UC and

screening is recommended after 8–10 years of the disease.150 The overall prevalence of CRC associated with UC has been reported at 3–5% MCE in the West151 and 0.0–2.2% in Asia.26,55,70,81,84,152,153 In many Asian studies cumulative incidence rates were not reported and there was a relatively short duration of follow-up. In a meta-analysis of studies from around the world, excluding Asian countries, the cumulative risk of CRC-associated with UC was reported to be 1.6%, 8.3% and 18.4% at 10, 20 and 30 years.154 CRC rates are comparatively lower in UC patients in India:82,155 0%, 1.0–2.3% and 5.8–7% at 10, 10–20 and > 20 years respectively, and in Japan:156 0.5%, 4.1%, and 6.1% at 10, 20 and 30 years, respectively. In 3922 patients from five hospitals in China,157 the overall prevalence of CRC in patients with UC was low at 0.87% but the cumulative risk of developing CRC was 1.15% at 10 years, 3.56% at 20 years, and 14.36% at 30 years, which is comparable to Western cohorts.

The components that will be discussed are flexibility, strength, sensoriomotor retraining (sometimes referred to as proprioception), balance and overall function. The role of each component will be explored, reviewed and linked to the management of musculoskeletal health for patients with haemophilia. Prior to embarking

on any kind of exercise programme, no matter what components A769662 of exercise are involved, it is recommended that all patients with haemophilia be evaluated by the multi-disciplinary health care team. This coordinated approach ensures that all medical and musculoskeletal issues will be identified and addressed as needed to enhance the efficacy of the exercise regimen. AP24534 purchase Commonly referred to as stretching, exercises with this focus are recommended to improve performance [2,3], as a warm-up prior to sports or activity to reduce or prevent injury [3–6], to decrease muscle soreness [4] and to gain range of motion (ROM) [7–10]. The benefits, however, of stretching to improve performance and reduce injury have come into question as reported by several review articles [11–14]. There are a variety of stretching techniques practised including static stretching, ballistic or dynamic stretching and proprioceptive neuromuscular facilitation (PNF) techniques. Static stretching is commonly referred to as slow stretching or passive stretching. Dynamic or ballistic

stretching involves bouncing motions or swinging a limb with momentum to stretch a muscle group. PNF stretching, such as the contract-relax technique, uses a combination

of isometric contractions and static stretches of the agonist and/or antagonist muscle, following the theory of autogenic and reciprocal inhibition. Stretching exercises result in elongation of soft tissues and muscles [15,16] that can have a lasting effect 24 h later, with the greatest increases being maintained in the first 15 min [17]. Viscoelasticity of skeletal muscle is affected, and 上海皓元 stress-relaxation occurs with a gradual reduction in tension as a stretch is held at a constant length over time [18,19]. In addition, a slow, sustained stretch stimulates the Golgi tendon unit, resulting in muscle relaxation [20] and reduces the spinal stretch reflex [21]. Stretching has been shown by many studies to increase ROM [7–10]. Some investigators, however, have proposed that stretching is responsible for decreasing strength directly after it is performed [22–24] while others have concluded that it either does not have an influence [25–27] or that it in fact increases strength [23,28–32]. Ballistic stretching causes facilitation of the stretch reflex [21,33] and could, in fact, injure the muscle fibres [34]. There are a multitude of articles relating to the non-bleeding disorder population on recommended practices for stretching exercise.

Conclusion: Serum CYFRA 21-1 represents a reliable diagnostic and prognostic biomarker of BTCs, especially for GBC and ICC. Disclosures: The following people have nothing to disclose: Li Huang, Wei Chen, Peiwen Liang, Wenjie Hu, Kunsong Zhang, Bin Chen, Yuyan Han, Fanyin Meng, Sharon DeMorrow, Xiaoyu Yin, Jiaming Lai, Lijian Liang Introduction: Hepatocellular carcinoma (HCC) develops on a continuum of morphological and molecular alterations in advancing chronic liver disease. FoxM1,

HKII, 8-OHdG, and iNOS have been implicated in a variety of cancers find more as markers for oncogenesis, increased metabolic activity, oxidative and nitrosative stress respectively. We hypothesize that these prooncogenic components act in concert to advance disease progression and influence tumor differentiation in HCC. Aims: To analyze immunomarkers of oncogenesis in non-dysplastic cirrhosis (NDC), liver cell change/dysplasia in cirrhosis (LCC), HCC and normal liver controls. Methodology: A progression liver tissue array 5-Fluoracil constructed from 45 subjects with cirrhosis and HCC, and 8 normal

controls was analyzed. Standard immunohistochemistry (IHC) was performed to determine levels of FOXM1, HKII, CD90, CD133, 8-OHdG, iNOS, CK7 and CK19. Staining was analyzed by Aperio Image Analysis. Fisher exact test was employed using SAS. Results: Strong positive correlations were found between various IHC stains and disease progression (Table 1). Tumor grade also correlated with CD90 hepatocyte cytoplasmic staining (CD90HS). Conclusions: Hepatocyte immunolevels of transcription factor FoxM1 and glycolytic enzyme HKII correlate with markers for hepatic cancer stem cells CD90 and CD133. Oxidative and nitrosative stress indicators medchemexpress 8-OHdG and iNOS correlate with fibrosis and disease progression markers CK7 and CK19. CD90 correlates with increasing tumor grade. These results further suggest FOXM1 and HKII play a role in promoting hepatocarcinogenesis. Disclosures: Costica Aloman – Advisory Committees or Review Panels: Gilead Sciences,

Janssen The following people have nothing to disclose: Lily Mei, Katherine M. Choi, Rajender Mulpuri, Dragana Kopanja, Hari Sreedhar, Michael J. Walsh, Ming Jin, Charmaine Stewart, Nissim Hay, Pradip Raychaudhuri, Grace Guzman Aim: Biologic features of hepatocellular carcinomas (HCCs) relate with the treatment and the prognosis. Thus, identification of biomarkers that can represent the biologic features of HCC is important. Previously, we isolated the side population (SP) cells from 2 HCC cell lines established from a single HCC nodule with histologic heterogeneity and confirmed that SP cells were more aggressive in biological features than non-SP ells in HAK-1B cells (J Gastroenterol Hepatol, 29:1092-1101, 2014).

Glia, and in particular astrocytes,

are vital in neuronal and CNS homeostasis. Increased expression of the astrocyte marker, glial fibrillary-associated protein (GFAP), implies neuroinflammation, linked with neuropathic pain and memory impairment. We determined whether 5-FU induced astrocyte activation via immune-to-CNS signaling pathways (neuronal vs humoral) and secondly, if astrocyte reactivity persisted beyond the intestinal injury. Materials and Methods: Female Dark Agouti rats (n = 8) were randomly allocated to saline control or 5-FU (i.p. 150 mg/kg) groups and tissues collected at either injury peak (day 3) or recovery (day 5). Western Blot analysis of hippocampal and thoracic sections determined GFAP and Interleukin-1

beta (IL-1β) expression. Myeloperoxidase (MPO) assay quantified intestinal inflammation. Statistical comparisons were conducted using Selleckchem Inhibitor Library a two-way ANOVA with Tukey’s post-hoc test. All data were expressed as mean ± SEM with p < 0.05 deemed statistically significant. Results: At injury peak (day 3), the bodyweight of 5-FU treated BVD-523 solubility dmso rats was 91% that of vehicle controls (p = 0.02) and MPO activity increased by 282% in the jejunum and 213% in the ileum compared to vehicle controls (p = 0.0007 and p = 0.0003, respectively). Although hippocampal GFAP expression showed little variance (p > 0.05), interestingly thoracic GFAP expression was significantly reduced by 28% in 5-FU treated rats compared to vehicle controls at injury peak of mucositis (day 5; p = 0.04),

yet normalized during the recovery phase (day 5; p > 0.05). IL-1β expression levels remained unchanged at both time-points. Conclusions: Down-regulation of thoracic GFAP expression is associated with astrocyte dysregulation in rats with 5-FU-induced mucositis; suggesting implications for CNS homeostasis and neuronal signaling. Further studies should clarify the role of glial dysregulation in 5-FU-induced mucositis and its potential implications 上海皓元 in chemotherapy-related side-effects, such as cognitive impairment and cancer-induced pain. KE FARRELL, BA GRAHAM, S KEELY, RJ CALLISTER School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW and Hunter Medical Research Institute, New Lambton Heights, NSW Introduction: Chronic abdominal pain is a common and debilitating symptom of Inflammatory Bowel Disease (IBD). Interestingly, 30–50% of patients continue to experience pain despite clinical remission. Although the mechanisms responsible for the development of chronic pain in this subset of IBD patients are unknown, there is evidence from animal studies that central nervous system (CNS) plasticity is involved1.

56, 95% CI=1.26-5.22, P = 0.01; OR=4.60, 95% CI=1.55-13.65, P = 0.006 for HCV genotype 1b patients). Interestingly, Patients with GC_rs222020 TC genotype are easily to have liver fibrosis (F2>7.3KPa) (OR=1.74, 95% CI=1.08-2.81, P = 0.023). We did not find any relationship between GC_rs7041, DHCR7 and treatment Erlotinib concentration response, neither did GC_ rs7041, CYP2R1, DHCR7 and liver fibrosis. Conclusions: In conclusion, CYP2R1 AA genotype

and GC_rs222020 TC genotype contribute to successful treatment outcome achievement, while GC_rs222020 TC genotype seems to lead to a higher pick-up rate of liver fibrosis. Association between CYP2R1, GC_rs222020 and treatment response in chronic HCV infected patients treated with IFN-α2b/ ribavirin M: major allele; m: minor allele; RVR: rapid viral response; CEVR: complete early Opaganib ic50 viral response; ETVR:

end of treatment viral response. Disclosures: The following people have nothing to disclose: Ruqi Mei, Yu Pan, Xiumei Chi, Xiaomei Wang, Ruihong Wu, Xiuzhu Gao, Jinglan Jin, Ge Yu, Jing Jiang, Junqi Niu Background: HCV infection is a leading contributor toward advanced liver disease, transplantation, and liver-related deaths in Argentina. A modeling approach was used to estimate the progression of the HCV epidemic and measure the burden of HCV-related morbidity and mortality. Methods: Age- and gender-defined cohorts were used to follow the viremic population in Argentina, and estimate HCV incidence, prevalence, hepatic complications, and mortality. Base case assumptions MCE were derived from the literature

and country-specific data sources. The relative impact of two scenarios on HCV-related outcomes was assessed: 1) increased sustained virologic response (SVR), and 2) increased SVR and treatment. Results: Under the base case, viremic prevalence is estimated to have peaked in 2002 (381,840 cases), declining 12% to 337,120 by 2014. Incident cases peaked at 22,340 in 1989, declining 91% to 1,900 cases in 2014. It is estimated that 70% of the infected population was born between 1950 and 1975 in 2014. By 2030, the infected population is projected to decline to 237,420 cases, a 30% decrease from 2014 (337,120 cases), largely due to mortality. Compensated cirrhosis is projected to peak at 63,000 cases after 2030, a 62% increase from 2014, while decompensated cirrhosis will peak after 2030 at 8,580 cases, an 81% increase from 2014. HCC cases also peak after 2030 at 3,760 cases, a 93% increase from 2014. Under Scenario 1, SVR increased to 85% (G3), 90% (G1/4) and 95% (G2) in 2016. Compared to the base case, there was a 0.3% reduction in prevalent cases, and a 0.2% reduction in liver-related deaths by 2030. Given low treatment rates, incident cases of liver cancer and decompensated cirrhosis decreased <1%, as compared to the base case in 2030. Under Scenario 2, the same increases in SVR were modeled, with gradual increases in the annual diagnosed and treated populations to 14,800 and 12,000 cases, respectively.

Methods: Consecutive patients with heartburn and/or acid regurgitation in outpatient and twenty-eight healthy controls were enrolled. The patients were considered as GERD if they had any of the following situations: reflux esophagitis (RE), abnormal esophageal 24 hrs pH monitoring and/or positive symptom index (SI), positive response to proton pump inhibitor (PPI) test. HRM were performed in GERD and healthy controls with ten wet swallows and ten viscous swallows in supine position. Results: Ninety-six GERD were enrolled including 37 RE patients and 61 males. GERD had lower bolus clearance rate and lower distal contractile integral (DCI) for both wet swallows and viscous swallows

comparing with healthy controls. GERD had decreased DCI (1078.5 ± 697.0 VS. 950.0 ± 616.0 mmHg●s●cm, CX-5461 chemical structure P = 0.001) and decreased contractile NVP-LDE225 front velocity (CFV) (4.8 ± 1.5 VS. 4.4 ± 1.4 cm/s, P = 0.000) in viscous swallows than that in wet swallows. RE patients had lower DCI (764.7 ± 675.4 VS. 1067.2 ± 550.6 mmHg●s●cm,

P = 0.031) than non-erosive reflux disease (NERD) in viscous swallows. Patients with abnormal pH monitoring and normal pH monitoring showed no significant differences in DCI. Conclusion: Esophageal peristalsis in GERD patients was weaker comparing with healthy controls and during viscous swallows. The peristaltic function of distal esophagus in GERD was probably related to mucosal break rather than acid exposure. Key Word(s): 1. GERD; 2. HRM; 3. NERD; Presenting Author: JIAYUAN ZHUANG Additional Authors: ZEHAO ZHUANG, DUPENG TANG, LIBIN LI, YILIN ZEN, JINGWEN SUN, FANGMING ZOU, JINGJING WEI Corresponding Author: ZEHAO ZHUANG Affiliations: The college of nurse, Fujian Medical University; Department of Gastroenterology, The first affiliated hospital of Fujian Medical University; Department of Gastroenterology,

Xiamen hospital of TCM; Department of Gastroenterology, Fuqing municipal hospital Objective: There are few data on the epidemiology of gastro-esophageal reflux disease (GERD) in Hakka population. This study was aimed MCE to assess the prevalence of GERD symptoms in Hakka population and to evaluate the effects of GERD symptoms on health-related quality of life. Methods: A face-to-face interview was carried out using a validated Chinese Gastro-esophageal reflux disease Questionnaire (CGQ) to evaluate the prevalence of GERD symptoms in a selected Hakka population in Youding County, Fujian Province. A randomly clustered sampling of permanent inhabitants aged 18 to 82 years was carried out in this Hakka’s community. The effects of GERD symptoms on health-related quality of life were evaluated by SF-36 (Chinese version). Results: A total of 203 residents (104 M, 99 F) were investigated. Median age of the responders was 43 years; while the response rate was 97.6%.