Recent findings

With recent improvements in prehospital care, trauma specialists face more challenging cases than ever before. Hemostatic transfusion strategies, with early and more aggressive use of plasma, platelets, cryoprecipitate and coagulation factor isolates, decrease blood loss in trauma patients. Combined with point-of-care testing for thromboelastography, coagulation panels, lactate and local rho O(2), there is an opportunity for frontline trauma clinicians to directly improve patient outcomes.

Summary

Although mortality previously was thought to be summarily independent of medical interventions selleck kinase inhibitor and resuscitations, we

now know the opposite to be true; it is our expectation and indeed our obligation to recognize and manage the coagulopathy of trauma better than in past years. In as much as we continue to prevent acidosis, hypothermia and the progressive coagulopathy following injury, trauma victims the world over are benefiting and surviving longer, living proof that demonstrates the utility of managing the coagulopathy of trauma.”
“Quality by design (QbD) and process analytical technology (PAT) have become priorities for the Center for Drug Evaluation and Research (CDER) at FHPI the Food and Drug Administration (FDA). Numerous recent initiatives within CDER and FDA have had the objective of encouraging the pharmaceutical industry to utilize QbD and PAT in their product development

and manufacturing processes. learn more Although sterile products

may be a minority compared to non-sterile dosage forms (e.g., solid orals), their absolute requirement for sterility make design and control of the manufacturing processes extremely critical. This emphasis on the manufacturing process makes the sterile drug product an obvious target for QbD and PAT. Although the FDA encourages QbD submissions, the utilization of QbD and PAT for sterile products so far is still limited. This paper will examine the present state of QbD and PAT for sterile products and review some examples currently in use. Additional potential applications of QbD and PAT for sterile product development and manufacturing will also be discussed.”
“The “”overlap syndrome”" is the concurrence of chronic obstructive pulmonary disease (COPD) with obstructive sleep apnea (OSA). This condition is not particularly well defined, and there is a paucity of data about the effects of any specific treatment on its outcomes. Until now, optimum treatment of the overlap syndrome could probably be best described as optimum treatment of each of its components, and there was no specific reason to think that treating one part of the syndrome would ameliorate the other part. However, recent observational data have demonstrated improved survival and reduced exacerbations in patients with the overlap syndrome who are treated with continuous positive airway pressure (CPAP).