Breast Cancer Res 2003, 5:18–24 CrossRef 18 Stoll BA: Western nu

Breast Cancer Res 2003, 5:18–24.CrossRef 18. Stoll BA: Western nutrition and the insulin resistance syndrome: a link to breast cancer. Eur J Clin Nutr 1999, 53:83–7.PubMedCrossRef 19. Friedenreich CM, Courneya KS, Bryant HE: Case control study of anthropometric measures and breast cancer risk. Int J Cancer 2002, 99:445–52.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions IC realized the protocol design, EE wrote the draft and edited the manuscript. FP revised critically the manuscript. AG has given final approval of the version to be published. MM, AC and MG contributed to the

statistical design. NM recruited metabolic syndrome affected women. GDA and GC conceived the study idea, supervised the study design. SL and TP supervised the protocol development. MDA and AF recruited patients for the study and

selected patients at risk of breast cancer. Aurora Kinase inhibitor EC and GE took blood samples and analyzed them in the lab. GB has contributed in data managing and preparing informed consent. All authors read and approved the final manuscript.”
“Introduction Liver metastases are a significant cause of morbidity and mortality for more than 45% of patients who present with colorectal PRI-724 order cancer (CRC) [1]. Although chemotherapy regimens combined with biologic agents have improved the control of liver metastases, the occurrence of hepatic metastases continues to present a life-limiting prognosis for most patients with advanced CRC [2] being 5 year survival approximately 11%. In the setting of clinical trials, median overall survival for unresectable metastases have been extended beyond two years using combinations including oxaliplatin, irinotecan, capecitabine and biologic agents (bevacizumab, cetuximab, panitumumab) [3, 4]. In parallel with these developments, the application of

locally ablative procedures, such as radiofrequency ablation, are increasingly considered beneficial for patients with unresectable liver-only disease who present with tumors ≤ 3–4 PJ34 HCl cm in diameter. These regional treatments for liver metastases can also be used to consolidate the treatment response with chemotherapy, in order to further increase the number of patients eligible for resection [5, 6]. Despite these gains, one of the major challenges in advanced CRC are the growing proportion of patients who continue to present with progressive liver involvement having exhausted all other therapeutic options. Radioembolization with yttrium-90 (90Y-RE) and, as recently described, with holmium-166 poly (L-lactic acid) labeled microspheres (166Ho-PLLA-MS) [7], are therapeutic procedures applied to the liver that allow direct delivery of high-dose radiation to liver tumors (both primary and metastatic) by means of endovascular catheters, selectively placed within the hepatic arterial vasculature.

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