At a fluid path length below 400 nm, atomic resolution images can be obtained and simultaneous compositional analysis can be achieved. learn more We show that EEL spectroscopy can be used to quantify the total fluid path length around the nanoparticle and demonstrate that characteristic core-loss signals from the suspended nanoparticles can be resolved and analyzed to provide information on the local interfacial chemistry with the surrounding environment. The combined approach using aberration-corrected STEM and EEL spectra with the in situ fluid stage demonstrates a plenary platform for detailed investigations of solution-based catalysis.”
“Objective:

Given increasing concern about the adverse effects of anti-tumor necrosis factor alpha (anti-TNF-alpha) medications, we sought to characterize psoriasiform eruptions in patients on these medications. Methods: In a retrospective review of patients at the Brigham and Women’s Hospital combined dermatology-rheumatology clinic, we identified 13 patients (1 male and 12 female patients) who developed psoriasiform eruptions while on anti-TNF-alpha medications. Results: Inciting medications were adalimumab,

etanercept, and Selleckchem Z VAD FMK infliximab. Patients were on their inciting medication for a median time of 24 months and a mean time of 31.3 months before developing eruptions. Five of 7 patients experienced complete resolution of lesions with topical corticosteroids and discontinuation of anti-TNF-alpha medications with the remaining

2 patients having partial improvement. One of the other 6 patients experienced complete resolution with topical corticosteroid treatment only, with the remaining 5 patients experiencing partial improvement. After changing anti-TNF-alpha agents, 1 patient had partial improvement of psoriasiform lesions, and 7 patients had no improvement. Conclusions: All of the main anti-TNF-alpha medications currently used are capable of causing psoriasiform eruptions. Poor responders to topical agents, such as corticosteroids, may benefit from supplemental therapy aimed at the psoriasiform eruption or changing to a different class of immunomodulatory agents. Switching anti-TNF-alpha medications selleck compound had a low likelihood of improving psoriasiform skin reactions, further suggesting that these eruptions are a drug class effect.”
“Protein-protein interactions (PPIs) are involved in the majority of biological processes. Identification of PPIs is therefore one of the key aims of biological research. Although there are many databases of PPIs, many other unidentified PPIs could be buried in the biomedical literature. Therefore, automated identification of PPIs from biomedical literature repositories could be used to discover otherwise hidden interactions.