We evaluated the heterochromatin associated with chromosomes in 50 leukemia patients,

93 drug addicts and 93 healthy controls from Tehran, Iran. Barium hydroxide saline Giemsa staining was used to examine heterochromatin polymorphism of selleck chromosomes 1, 9 and 16 in lymphocyte cultures. There were significant differences in this polymorphism in lymphocytes from drug addicts and leukemia patients compared to healthy controls. These polymorphisms could serve as markers for the detection and characterization of chromosome damage in leukemia patients and drug addicts.”
“We calculate the collision cross section of a charged finite cylinder (nanowire) with a beam of ions and electrons in collisionless plasma. We find that, while the shape and area of the cross section has complex dependence on the charge and orientation of the nanowire relative to the charged beam, its orientational average has a remarkably simple form: for attractive interactions, it is a linear function of the electrostatic ratio q(j)q(p)e(2)/4 pi epsilon(0)L(0)kT, where q(j)e is the charge of the ions/electrons, q(p)e is the charge on the cylinder, L(0) is the half-length of the TH-302 nanowire, T is the temperature of the charged species, and epsilon(0) is the permittivity of free space. This linearity persists into the repulsive regime up until the cross sectional area is reduced to about 5% of its value for neutral

collisions. We calculate the corresponding charging currents

and show that the charging behavior of the nanowire in Maxwellian plasma is described by an equivalent sphere whose radius depends only on the aspect ratio of the nanowire. For small aspect ratios, the equivalent sphere has the same surface area as the nanowire. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3483300]“
“Acute effects of sex steroid hormones likely contribute to the observation that post-pubescent males have shorter QT intervals than females. However, the specific role for hormones in modulating cardiac electrophysiological parameters and arrhythmia vulnerability is unclear. Here we use a computational modeling approach to incorporate experimentally measured effects of physiological concentrations of testosterone, estrogen and progesterone on cardiac ion channel CP-868596 chemical structure targets. We then study the hormone effects on ventricular cell and tissue dynamics comprised of Faber-Rudy computational models. The “”female” model predicts changes in action potential duration (APD) at different stages of the menstrual cycle that are consistent with clinically observed QT interval fluctuations. The “”male” model predicts shortening of APD and QT interval at physiological testosterone concentrations. The model suggests increased susceptibility to drug-induced arrhythmia when estradiol levels are high, while testosterone and progesterone are apparently protective.