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“Gamma irradiation can induce beneficial as well as deleterious impacts on chromosome behavior in crop plants. The cytogenetic changes occurring due to the storage of inbred seeds after gamma irradiation in the somatic and gametic cells of Zea mays L. were investigated in this study. A wide spectrum of chromosomal anomalies was encountered in somatic and gametic cells of maize that are gamma irradiated, stored (aged), and treated with a combination of both of these treatments. Gamma rays and ageing treatments induced

a number of chromosomal anomalies independently, NSC-23766 but a combination of the 2 treatments suppressed the frequency of chromosomal anomalies considerably in somatic as well as gametic cells of maize. It is evident from our study that the decrease in mitotic index was inversely proportional to the increase in doses in all the sets of gamma rays and ageing treatments. The conclusion drawn from our study is that individual treatment

of gamma rays induced the highest percentage of chromosomal abnormalities, followed by the combination treatment of ageing and gamma rays, and the least number of abnormalities were induced by the individual treatment of ageing. Hence, the combination treatment proved to be better in the mechanism of genetic repairing, which is discussed in the present study.”
“Background aims. In patients with inflammatory bowel disease infected with hepatitis B virus (HBV), immunosuppressive therapy required to suppress active inflammatory bowel disease may promote HBV reactivation. Methods. A 27-year-old corticosteroid-naive woman SCH727965 research buy with Crohn’s disease (CD) activity index of 249.8 complicated by HBV infection was offered Entecavir to control HBV reactivation during immunosuppressive

therapy for CD. The patient refused Entecavir, fearing that it might adversely affect her pregnancy outcome. Instead, we applied intensive granulocyte/monocyte adsorptive apheresis (GMA) at two sessions per week to deplete inflammatory cytokine-producing leucocytes as an immunosuppressive therapy in this case. Results. GMA induced stable remission (CD activity index, I 105) and endoscopic improvement without HBV reactivation or Gamma-secretase inhibitor safety concern. Furthermore, CD remission was paralleled by suppression of tumor necrosis factor and interleukin as measured in serum samples. Conclusions. Immunosuppressive therapy required to treat an active CD potentially can promote HBV reactivation and worsen liver function. In this study involving a CD case complicated by chronic HBV infection, intensive GMA as a non-pharmacologic treatment intervention was associated with clinical remission and endoscopic improvement without HBV reactivation. Furthermore, GMA was well-tolerated and was without any safety concern. However, suppression of tumor necrosis and interleukin-6by GMA in this clinical setting is potentially very interesting.