These results were expressed as the concentrations that induce 50% inhibition of cell growth (IC50) in mu g/mL. Considering that, compounds 3b, 3e, 3h, 3n, 3r and 3u exhibited good cytotoxic activity against at least three cancer cell lines (0.7967-4.200 mu g/mL). In general, we observed that the presence of electron-withdrawing groups in the benzene ring is important for the anticancer activity in this series, such as fluorine (3h), chlorine (3b) amd bromine (3e) groups in meta position and nitro group (3r) in para position. These derivatives

could be considered interesting start points to develop a new anticancer drug and confirm the potential of chloroquine derivatives as lead compounds BTK inhibitor in anticancer drug discovery.”
“The negatively-charged nitrogen-vacancy (NV) center is the most studied optical center in diamond and is very important for applications in learn more quantum information science. Many proposals for integrating NV centers in quantum and sensing applications rely on their tailored fabrication in ultra pure host material. In this study, we use ion implantation to controllably introduce nitrogen into high purity, low nitrogen chemical vapor deposition diamond samples. The properties of the resulting NV centers are studied

as a function of implantation temperature, annealing temperature, and implantation fluence. We compare the implanted NV centers with native NV centers present deep in the bulk of the as-grown CP127374 samples. The results for implanted NV centers are promising but indicate, at this stage, that the deep native NV centers possess overall superior optical properties. In particular, the implanted NV centers obtained after annealing at 2000 degrees C under a stabilizing pressure of 8 GPa showed an ensemble linewidth of 0.17 nm compared to 0.61 nm after annealing at 1000 degrees C.

Over the same temperature range, the ensemble NV-/NV0 ratio increased by a factor of similar to 5, although this was accompanied by an overall decrease in the NV count. (C) 2011 American Institute of Physics. [doi:10.1063/1.3573768]“
“Epileptic seizures have historically been associated with religious beliefs in spirit possession. These attitudes and misconceptions about epilepsy still flourish in developing countries as byproducts of specific sociocultural environments. This article presents a case series of four Haitian patients with epilepsy whose seizures were initially attributed to Voodoo spirit possession. All patients reported ictal experiential phenomena (epigastric aura, ictal fear, depersonalization, and derealization symptoms) followed by complete loss of consciousness. Electroclinical investigations revealed a temporal lobe focus.