Their abundance and low cost makes them a preferred choice for use in food and pharmaceuticals. The gum obtained from unripe fruits of Aegle marmelos is edible and has been recommended in ancient system of medicine for
medicinal uses. However, its physico-chemical properties have not been evaluated. The gum particles obtained after freeze drying were observed to possess rough surface and moderate negative charge AZD7762 of -16.7 mV. They exhibited fair flow (angle of repose 37.2 degrees) and moderate compressibility (Carr’s Index 17.65%) desired of an excipient. High swelling index (4.2) and better emulsion stability and capacity than gum arabic indicated its promising functionality in pre-disperse systems. In addition, high degree of substitution (7.4) could be utilized for derivatization/interaction with
other polymers for modifying the drug release profiles. (C) 2013 Elsevier B.V. All rights reserved.”
“A 7-month-old baby presented with a 4-day history of drowsiness and vomiting after a falling accident. Magnetic resonance imaging demonstrated diffuse subarachnoid hemorrhage, intraventricular hemorrhage, and variable stages of subdural hematoma in bilateral occipital and left temporal subdural spaces. A partially thrombosed aneurysm was noted in the right craniocervical junction. Ophthalmological examination revealed bilateral retinal petechial hemorrhages. Conventional cerebral angiography revealed CT99021 chemical structure a dissecting aneurysm in the right posterior inferior cerebellar artery (PICA). Endovascular embolization was suggested, but the family refused. After conservative treatment, follow-up MRI revealed that the PICA aneurysm had remodeled and ultimately disappeared completely at the 10th month. This case illustrates MRT67307 nmr the relatively plastic nature of intracranial aneurysms in pediatric patients. More studies are necessary to clarify the natural history of spontaneously thrombosed aneurysms to assist in their overall management.”
“Objectives: Electrical stimulation of calf muscles has been shown to be effective in prevention of DVT. The aim was to determine: (a) dependence of venous blood velocity and
ejected volume on the rates of stimulated calf contractions: (b) clinical factors affecting efficacy in healthy individuals.
Methods: The maximum intensity stimulus tolerated was applied to calfs of 24 volunteers. In popliteal veins, Peak Systolic Velocities (PSV), ejected volume per individual stimulus (Stroke Volume SV) and ejected Total Volume Flow per minute (TVF) of expelled blood were determined using ultrasound. Stimulation rates from 2 to 120 Beats Per Minute (bpm) were applied.
Results: Mean baseline popliteal PSV was 10 cm/s. For stimulation rates between 2 and 8 bpm, the PSV was 10 times higher and reached 96-105 cm/s. Stroke volume (SV) per individual stimulus decreased in a similar fashion. With increasing rates of stimulation the TVF increased by a factor of 12 times (from 20 ml/min to 240 ml/min).