Synthesis of other compounds like toxic lipodepsipeptide, siderophores, and HCN was also confirmed by appropriate biochemical tests.
Conclusion: Characterization of strain Psd by various biochemical/plate tests followed by chromatographic identification of antibiotics, demonstrates its multifunctional biocontrol property. Response regulator gene gacA provides an additional genetic marker for the phylogenetic studies.
Significance and Impact of the Study: Ps. fluorescens
see more strain Psd with its multifunctional biocontrol property can be used to bioprotect the crop plants from phytopathogens.”
“Aims: The interactions between nonsteroidal anti-inflammatory drugs (NSAID) and Listeria monocytogenes have not been sufficiently documented to date. The aim of this study was to investigate the possible effects of Diclofenac (Dc) in a murine listerial infection model.
Methods and Results: Dc was administered orally at 2.5 mu g g(-1) to female albino strain of laboratory mouse (BALB/c) thrice postinfection (1 x 10(8) CFU ml(-1) oral challenge with L. monocytogenes ATCC 51774), which resulted in significantly (P < 0.01) reduced bacterial counts in liver and spleen, decreased (10-fold, P < 0.05) hepatic PD-1/PD-L1 Inhibitor 3 mw colonization and necrosis, and caused up-regulation of
the expression of inflammatory cytokines (interferon-gamma, interleukin-1 beta, tumour necrosis factor-alpha), compared with drug-free control.
Conclusions: Dc may be useful as a promising adjuvant to the existing therapies in controlling systemic listerial infection. Further, quantitative structure-activity relationship studies might contribute in manipulating it as a lead
compound for the synthesis of new, more effective nonantibiotics, perhaps, devoid of side-effects that could be recommended as a compassionate therapy for listeriosis.
Significance and Impact of the study: This is the first in vivo study designed to evaluate the antilisterial effect of the NSAID Dc with special emphasis on the immunological mechanism of action of the drug.”
“Aims: To select a carotenoid-hyperproducing mutant and to formulate pineapple juice as a carotenoid production medium.
Methods and Results: Pritelivir chemical structure Yeast strain of Xanthophyllomyces dendrorhous mutant GM 807 (derived from gamma irradiation) and the mutant n78 (from neutron irradiation) were selected based on higher carotenoid production in diluted pineapple juice as a medium. The selected strain was evaluated under various concentrations of pineapple juice. The results obtained in the study demonstrate that the mutant GM 807 enhanced production by 65.8% when using pineapple juice as medium at 10% dilution in place of yeast malt medium.
Conclusion: Pineapple juice could be used as a sole medium for carotenoid production.
Significance and Impact of the Study: Our results provide useful information for the design of production media for carotenoids to be used in various applications.