Statistical correlation trends were analyzed using Spearman’s rank coefficient as related to

VCSS.

Results: Five thousand eight hundred fourteen limbs in 2,907 participants were screened and included CEAP clinical stage CO: 26%; Cl: 33%; C2: 24%; C3: 9%; C4: 7%; C5: 0.5%; C6: 0.2% (mean, 1.41 +/- 1.22). VCSS mean score distribution (range, 0-3) for the entire cohort included: pain 1.01 +/- 0.80, varicose veins 0.61 +/- 0.84, edema 0.61 +/- 0.81, pigmentation 0.15 +/- 0.47, inflammation 0.07 +/- 0.33, induration 0.04 +/- 0.27, ulcer number 0.004 +/- 0.081, ulcer size 0.007 +/- 0.112, ulcer duration 0.007 +/- 0.134, and compression 0.30 +/- 0.81. Overall selleckchem correlation between CEAP and VCSS was moderately strong (r(s) = 0.49; P < .0001), with highest correlation for attributes reflecting more advanced disease, including varicose vein (r(s) = 0.51; P < .0001), pigmentation (r(s) = 0.39; P < .0001), inflammation (r(s) = 0.28; P < .0001), induration (r(s)

= 0.22; P < .0001), and edema (r(s) = 0.21; P < .0001). Based on the modified CIVIQ assessment, overall mean score for each general category included: Quality of Life (QoL)-Pain 6.04 +/- 3.12 (range, 3-15), QoL-Functional 9.90 Pifithrin-�� supplier +/- 5.32 (range, 5-25), and QoL-Social 5.41 +/- 3.09 (range, 3-15). Overall correlation between CIVIQ and VCSS was moderately strong

(r(s) = 0.43; P < .0001), with the highest correlation noted for pain (r(s) = 0.55; P < .0001) and edema (r(s) = 0.30; P < .0001). Based on screening venous ultrasound results, 38.1% of limbs had reflux and 1.5% obstruction in the femoral, saphenous, or popliteal vein segments. Correlation between overall venous ultrasound findings (reflux + obstruction) and VCSS was slightly positive (r(s) = 0.23; P < .0001) but was highest for varicose vein (r(s) = 0.32; P < .0001) and showed no correlation to swelling (r(s) = 0.06; P < .0001) and pain (r(s) Elesclomol (STA-4783) = 0.003; P = .7947).

Conclusions: While there is correlation between VCSS, CLAP, modified CIVIQ, and venous ultrasound findings, subgroup analysis indicates that this correlation is driven by different components of VCSS compared with the other venous assessment tools. This observation may reflect that VCSS has more global application in determining overall severity of venous disease, while at the same time highlighting the strengths of the other venous assessment tools. (J Vase Surg 2011;54:2S-9S.)”
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