Methods. The study included cancer patients >= 70 years old referred to an oncology clinic for chemotherapy. Information on comorbidities, disability in instrumental activities of daily living (IADL) and activities of daily living (ADL), and seven frailty markers (nutrition, mobility, strength, energy, physical activity, mood, and cognition) was collected. Patients were classified selleck compound into four hierarchical groups: 1- No frailty markers, IADL, or ADL disability; 2-Presence of frailty markers without IADL or ADL disability; 3- IADL disability without ADL disability; 4- ADL disability.
Results. Among the 50 patients assessed, 6 (12.0%) were classified into Group 1, 21 (42.0%) into Group 2,
15 (30.0%) into Group 3, and 8 (16.0%) into Group 4. In Group 2, 7 patients (33.3 %) had one frailty marker, and 14 (66.7%) had two or more. The most prevalent of the frailty markets were nutrition, mobility, and physical activity.
Conclusion. The assessment of seven frailty markers allowed the detection of potential vulnerability
among 42% of older cancer patients that would not have been detected through an assessment of IADL and ADL disability alone. A longitudinal study is needed to determine whether the use of frailty markers can better characterize the older cancer population and predict adverse outcomes due to cancer treatment.”
“OBJECTIVE: Optimal surgical management in lateral ventricle tumors remains controversial. We conducted a retrospective study of patients with these lesions treated with a surgical Z-IETD-FMK research buy strategy on the basis of tumor origin: primary or secondary ventricular and associated transependymal development.
METHODS: PDK inhibitor A total
of 72 patients underwent surgery for lateral ventricle tumors. The mean patient age was 39 years (range, 6 mo to 78 yr). Raised intracranial pressure occurred in 53% of patients, followed by mental disturbances or psychiatric symptoms (32%) and motor deficits (21%). The transcortical approach was used in 44 patients, and an interhemispheric approach was used in 28 patients; a transcallosal approach was used in 16 patients, and a parasplenial approach was used in 12 patients. Neuropsychological tests were performed in selected patients.
RESULTS: Total resection was performed in 82% of patients. Sixty-five percent of tumors were benign and low-grade tumors. There was no surgical mortality, and the morbidity rate was 11%. Postoperative epilepsy (5.9%) was significantly increased in the transcortical group. The mean follow-up period was 55 months; 59% of patients achieved good recovery and moderate disability. In postoperative neuropsychological testing sessions, deficits in verbal memory were observed in six patients (8%). Final morbidity correlated well with preoperative clinical condition and pathological diagnosis.
CONCLUSION: Lateral ventricle tumors can be treated hest by careful selection of the approach according to tumor origin and development it.