Med Care 2007, 45:1195–1204 PubMedCrossRef 59 Meyers FJ, Linder

Med Care 2007, 45:1195–1204.PubMedCrossRef 59. Meyers FJ, Linder J: Simultaneous care: disease treatment and palliative AZD9291 care throughout illness. J Clin Oncol 2003, 21:1412–1415.PubMedCrossRef 60. Lagman R, Walsh D: Integration of palliative medicine into comprehensive cancer care. Semin Oncol 2005, 32:134–138.PubMedCrossRef 61. Malin JL: Bridging the divide: integrating cancer-directed therapy and palliative care. J Clin Oncol 2004, 22:3438–3440.PubMedCrossRef 62. Gelmon SB: Accreditation, core curriculum and allied health education: barriers and opportunities. J Allied Health 1997, 26:119–125.FK866 molecular weight PubMed 63. Insalaco

D, Ozkurt E, Santiago D: Attitudes and knowledge of students in the allied health professions toward their future professional team members. J Allied Health 2006, 35:142–146.PubMed 64. Strohschein this website J, Hagler P, May L: Assessing the

need for change in clinical education practices. Phys Ther 2002, 82:160–172.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions MB conceived the paper, interpreted data and wrote the final manuscript; CZ conceived the paper, interpreted data and wrote the final manuscript; AP reviewed and commented the last version of the manuscript; AMDN helped to revise the first draft of the manuscript; MS and GS reviewed and commented the last version of the manuscript; FP interpreted data, reviewed and commented the last version of the manuscript. All authors read and approved the final manuscript.”
“Background The lymphatic system functions in regulating tissue fluid balance and immune cell trafficking, and it is involved in the pathogenesis of edema and metastasis. Tumor cell dissemination to lymph nodes (LNs) through the lymphatic system is common and early event in human malignant tumors. LN metastasis is the first sign of tumor progression in most malignant tumors, and is a crucial determinant in their staging, prognosis,

and treatment [1]. Lymphatic metastasis was considered a passive process, where detached tumor cells entered LNs via pre-existing lymphatic vessels proximate to the primary tumors [2]. Sentinel LNs (SLNs) Obatoclax Mesylate (GX15-070) are defined as the first LNs to receive cells and fluid from primary tumors through lymphatic vessels [3]. Malignant cells at SLNs were believed to then enter the blood stream via high endothelial venules or continue through the lymphatic drainage system, exiting into the blood stream via anastomoses such as the thoracic duct [4]. Changes in LNs begin before metastasis, a process termed tumor-reactive lymphadenopathy [5]. Regional LNs proximate to the primary tumors are commonly enlarged because of reactive lymphadenopathy, tumor metastasis, or both, suggesting that LN alteration results from interactions between tumors and the lymphatic system.

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