It continued bilaterally to temporal and frontal poles by 290 ms. Subtraction of nonattended from attended conditions removed primarily the early contralateral sensory components. There was some indication of a preferred order of sensory processing that may express and optimize hemispheric computational specializations. Results indicate similar functional organizations for tactile and visual pattern recognition. NeuroReport 20:941-945 (C) 2009 Wolters Kluwer Health check details | Lippincott Williams & Wilkins.”
“MicroRNAs (miRNAs) represent a conserved

class of small noncoding RNAs that are found in all higher eukaryotes as well as some DNA viruses. miRNAs are 20 to 25 nucleotides in length and have important regulatory functions in biological processes such as embryonic development, cell differentiation,

hormone secretion, and metabolism. Furthermore, miRNAs have been implicated in the pathology of various diseases, including cancer. miRNA expression profiles not only classify different types of cancer but also may even help to characterize distinct tumor stages, therefore constituting a valuable tool for prognosis. Here we report the miRNA profile of Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) tissue samples characterized by cloning and sequencing. We found that all EBV miRNAs LDN-193189 price from the BART region are expressed in NPC tissues, whereas EBV miRNAs from the BHRF1 region are not found. Moreover, we identified two novel EBV miRNA genes originating from the BART region that have not been found in other tissues or cell lines before. We also identified three new human miRNAs which might be specific for nasopharyngeal tissues. We further show that a number of different cellular miRNAs, including miR-15a Tideglusib and miR-16, are up- or downregulated in NPC tissues compared to control tissues. We found that the tumor suppressor BRCA-1 is a target of miR-15a as well as miR-16, suggesting a miRNA role in NPC pathogenesis.”
“TASK-2 is a member of tandem-pore domain potassium

channels that regulate neuronal excitability. In this study we investigated the expression of TASK-2 in neuronal elements in the inner retina of rat by immunofluorescence double labeling. In contrast to weak expression in the outer retina, TASK-2 is strongly expressed in the inner retina. TASK-2 immunoreactivity was diffusely distributed throughout the inner plexiform layer. Double-labeling experiments revealed that TASK-2 was expressed in gamma-aminobutyric acid amacrine cells (GABAergic amacrine cells), including both dopaminergic and cholinergic ones. The immunostaining appeared on the membrane, cytoplasm, and somatodendritic compartments of these cells. In All glycinergic amacrine cells, however, only faint punctuate staining, if any, was seen. In addition, ganglion cells were also intensely labeled by TASK-2. NeuroReport 20:946-950 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.