A molecule that binds the state of transition can catalyze this reaction. Since TSA in use imitated the geometric structure of a peptide bound hydrolysis,
Never Born Proteins positively selected could present peptidase activity. The selected Never Born Protein were characterized by spectroscopic methods like circular dichroism and their polypeptide sequence was analyzed by Rosetta method to have a structure prediction. Both EPZ-6438 assays showed the presence of a tertiary stable structure that is an essential prerogative of catalytic activity. The Never Born Proteins selected in this way are the best candidates to represent pre-biotic peptidase and besides they could have an advantageous catalytic activity compared with peptidases see more selected by the Nature and so they could been called Never Born Peptidase. This are
preliminary results, a starting point for future investigations, more random sequences will be selected, isolated and analyzed to better understand the Never Born Proteins’ structures and properties. De Duve C. (1995), Vital Dust: life as a cosmic imperative, Ed. Basic Book, New York Monod J. (1971), Chance and Necessity: an essay on the natural philosophy of modern biology, A.A. Knopf, New York E-mail: aquintarelli@uniroma3.it Dynamics of Pattern Formation in Biomimetic Systems F. Rossi1*, S. Ristori2 M. Rustici3, N. Marchettini4, E. Simoncini4, E. Tiezzi4 1Dipartimento di Chimica Fisica, Università di Palermo, Italy; 2Dipartimento di Chimica, Università di Firenze, Italy; 3Dipartimento di Chimica, Università di Sassari, Italy; 4Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi,
Flavopiridol (Alvocidib) Università di Siena, Italy Confinement into restricted spaces is an essential requirement for any process of life and it is thought to have played a mayor role in the emergence of the earliest living systems, by providing concentration of chemical and biological relevant species as well as protection from adverse external environment. In addition to confinement factors, cellular organization involves a complex interaction among structure, chemical kinetics, and transport processes. By using model systems where these features can be controlled to a large VS-4718 mouse extent independently of the others, the relative contribution of each aspect to cellular attributes can be inferred. The Belousov–Zhabotinsky (BZ) (Belousov 1958) reaction spontaneously produces complex spatial patterns (spirals, spots,…) that may oscillate in time or remain stationary and for this property it can be considered a valid model for self structuring and self patterning phenomena. Insights gained from the study of the BZ reaction carried out in biomietic matrices may shed light on the emergence of shape in living systems.