The ability of magnetic resonance imaging to visualize osteoarthritis as a regional and responsive (reversible) disease may lead to new paradigms for developing and applying lifestyle, medical, and surgical therapeutic interventions.”
“Primary oral mucosal melanoma is a rare aggressive tumor. Recent studies have demonstrated a correlation between increased tumor invasion and the metastatic phenotype and altered adhesion molecule expression profiles. The present study

Selleckchem Ispinesib analyzed the expression of integrins, claudins, and immunoglobulin-like adhesion molecules in oral mucosal melanomas and correlated results with clinical parameters. Immunohistochemical analyses of the expression patterns of these molecules were performed on thirty-five cases of primary oral mucosal melanomas organized in a tissue microarray. The results were correlated with clinical and histological features of the cohort. A number of integrin subunits were negative and this was related with vascular invasion. Positivity of integrin beta-3 and CD166 (activated leukocyte cell adhesion molecule) was statistically associated with extensive vascular invasion (P < 0.05). Lower expression of CD54 (intercellular cell Selleckchem GSK1120212 adhesion molecule) was associated with cases with extensive necrosis. Most cases with metastatic disease were negative for CD66 (carcinoembryonic antigen-related cell adhesion molecule). Several subunits of claudins were

negative and, although not statistically significant, this lack of expression was partially associated with histological factors of poor prognosis.

Altered patterns of adhesion molecule expression, mainly integrins and immunoglobulin-like proteins, may participate in the pathogenesis and outcome of oral mucosal melanomas.”
“Karl Peter provided the first detailed description of the structure and morphology of the human kidney and defined at least 9 major segments of the tubules. He showed that the nephrons were heterogeneous in their structure and could be divided in 2 categories: the short-looped and the long-looped ones. Peter’s scheme of the human nephrons was published in many journals and textbooks. Another contribution was the demonstration of a relationship between the relative occurrence of long thin loops Dinaciclib datasheet (versus short loops) and the maximal urinary concentration capacity. Peter was also the first to describe the cells of the macula densa, which are of fundamental importance in the tubulo-glomerular feedback mechanism. Furthermore, Peter gave a detailed description of the principal zones of the human kidney: the cortex, the outer medulla with outer and inner stripes, and the inner medulla.”
“Osteoarthritis is the most common joint disorder worldwide, and it has an enormous socioeconomic impact both in the United States and throughout the world. Conventional radiography is the simplest and least expensive imaging method for assessing osteoarthritis of the knee.

A necrotic background suggests a tubercular etiology of the granulomas over a sarcoidal one, in the appropriate clinical setting. Copyright (C) 2012 S. Karger AG, Basel”
“Background-Development check details of viral-induced chronic myocarditis is thought to involve both environmental and genetic factors. However, to date, no susceptibility genes have been identified.

Methods and Results-We sought to identify loci that confer susceptibility to viral-induced chronic myocarditis with the use of chromosome substitution strain mice that are composed of 1 chromosome from the disease susceptible A/J strain on an otherwise resistant

C57BL/6 background. By this method, we identified chromosome 17 to confer susceptibility. To further isolate the region of susceptibility, 8 strains of mice congenic for different portions of chromosome 17 were generated. Characterization of these strains identified at least 4 susceptibility GW3965 chemical structure loci on the chromosome. Three of these loci are located in the proximal 22.8 cM, whereas the fourth locus is located in the portion of the chromosome distal to 34.3 cM.

Conclusions-We have identified 4 loci that confer susceptibility of viral-induced chronic myocarditis. Of these

loci, 3 were distinct from the major histocompatibility complex locus and thus represent novel susceptibility loci. The close proximately of the 2 novel loci with susceptibility loci for other autoimmune diseases such as type 1 diabetes and chronic experimental autoimmune thyroiditis suggests the presence of global autoimmune susceptibility genes. (Circ Cardiovasc Genet. 2010;3:399-408.)”
“Background: The effect of acute lung injury on adhesion molecule expression in hematopoietic stem/progenitor click here cells (HSPCs) is poorly understood. Objectives: The aim of this study was to determine whether there is a

relationship between pulmonary inflammation, expression of VLA-4 (CD49d), LFA-1 (CD11a), L-selectin (CD62L), CXCR4, and chemotaxis in resident HSPCs, as well as the level of circulating HSPCs. Methods: Following intratracheal administration of a single LPS bolus in C57Bl/6 mice, the number of inflammatory cells, differential counts, and amounts of cytokines/chemokines were studied in cytospins and bronchoalveolar lavage fluid (BALF) specimens. Expressions of adhesion molecules and CXCR4 were analyzed in HSPCs by flow cytometry, as well as SDF-1-directed chemotaxis. Levels of HSPCs in the blood were studied in ungated and circulating subpopulations. Results: In coincidence with a peak of airway neutrophils, cytokine (IL-1 beta, TNF-alpha,and IL-6), chemokine (KC, MIP-2, and SDF-1) levels in BALF and the number of marrow HSPCs expressing CD49d and CXCR4 significantly increased at 48 h. The number of CD49d- and CXCR4-positive HSPCs dropped at 72 h. The HSPC subset comprising bigger cells behaved the same for CD49d.

Because of the fact that wood cell walls in the surface layer had apparently collapsed in the presence learn more of catalyst DETA and therefore the wood was densified, the PU-wood composite prepared with DETA had the best mechanical properties and dimensional stabilities. The PU prepolymer was well impregnated and evenly foamed within the wood in the presence of catalyst NMM, giving the PU-wood composite prepared With NMM Much better dimensional stability as the foamed PU blocked the water transfer between the cells. (c) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 12931299, 2009″
“Isoniazid preventive therapy (IPT) with

antiretroviral therapy (ART) reduces incident tuberculosis AP24534 Angiogenesis inhibitor among patients infected with the human immunodeficiency virus. We describe IPT use among patients on ART at two primary care clinics in South Africa. Of 597 participants interviewed, 100 (16.8%) reported IPT use; 73.4% (365/497) with no reported IPT use were eligible for IPT. IPT use was associated with age <35 years (aOR 1.90, 95%CI 1.18-3.06), and receiving care at one clinic as opposed to the other (aOR 4.72, 95%CI 2.69-7.93). The high proportion of patients on ART eligible for IPT represents a missed opportunity for IPT scale-up.”
“A neutral polysaccharide, coded as NTPS-1, was obtained from the crude tea polysaccharide (NTPS) of green tea (Camellia sinesis) by a DEAE-Sepharose fast How column. The polysaccharide

appeared to be homogenous with the weight of 21,247 Da by the high performance this website gel permeation chromatography (HPGPC) analysis. The NTPS-1 was found to consist of galactose. The structure of NTPS-1 was characterized by infrared (IR) spectrum, gas chromatography (GC), periodate oxidation, Smith degradation, 1D NMR and 2D NMR spectroscopy.

It was found that NTPS-1 was a galactan consisting of beta-(1 -> 4)-linked galactopyranosyl units. (c) 2009 Elsevier Ltd. All rights reserved.”
“This study was aimed at obtaining insight into the diversity of sialic acids in cancer-and non-cancer-related CA125 antigen, tumour marker of serous ovarian cancer. Starting from available data suggesting the possible relevance of sialic acids for discriminating CA125 antigens of different origin, we have employed a new experimental approach based on the use of human sialic acid-binding Ig-like lectins, Siglecs, as tools for the investigation of sialylation.

Siglec-2, belonging to the group of evolutionarily conserved Siglecs, and Siglec-3, -6, -7, -9 and -10, which are CD33-like Siglecs, were probed in solid-phase binding assays with cancer-related CA125 antigens from pleural fluid of patients with ovarian carcinoma (pfCA125), the OVCAR-3 ovarian carcinoma cell line (clCA125) and a non-cancer-related CA125 antigen, i.e. pregnancy-associated pCA125 antigen.

All Siglecs used showed detectable binding to pCA125 antigen.

Recent findings

With recent improvements in prehospital care, trauma specialists face more challenging cases than ever before. Hemostatic transfusion strategies, with early and more aggressive use of plasma, platelets, cryoprecipitate and coagulation factor isolates, decrease blood loss in trauma patients. Combined with point-of-care testing for thromboelastography, coagulation panels, lactate and local rho O(2), there is an opportunity for frontline trauma clinicians to directly improve patient outcomes.

Summary

Although mortality previously was thought to be summarily independent of medical interventions selleck kinase inhibitor and resuscitations, we

now know the opposite to be true; it is our expectation and indeed our obligation to recognize and manage the coagulopathy of trauma better than in past years. In as much as we continue to prevent acidosis, hypothermia and the progressive coagulopathy following injury, trauma victims the world over are benefiting and surviving longer, living proof that demonstrates the utility of managing the coagulopathy of trauma.”
“Quality by design (QbD) and process analytical technology (PAT) have become priorities for the Center for Drug Evaluation and Research (CDER) at FHPI the Food and Drug Administration (FDA). Numerous recent initiatives within CDER and FDA have had the objective of encouraging the pharmaceutical industry to utilize QbD and PAT in their product development

and manufacturing processes. learn more Although sterile products

may be a minority compared to non-sterile dosage forms (e.g., solid orals), their absolute requirement for sterility make design and control of the manufacturing processes extremely critical. This emphasis on the manufacturing process makes the sterile drug product an obvious target for QbD and PAT. Although the FDA encourages QbD submissions, the utilization of QbD and PAT for sterile products so far is still limited. This paper will examine the present state of QbD and PAT for sterile products and review some examples currently in use. Additional potential applications of QbD and PAT for sterile product development and manufacturing will also be discussed.”
“The “”overlap syndrome”" is the concurrence of chronic obstructive pulmonary disease (COPD) with obstructive sleep apnea (OSA). This condition is not particularly well defined, and there is a paucity of data about the effects of any specific treatment on its outcomes. Until now, optimum treatment of the overlap syndrome could probably be best described as optimum treatment of each of its components, and there was no specific reason to think that treating one part of the syndrome would ameliorate the other part. However, recent observational data have demonstrated improved survival and reduced exacerbations in patients with the overlap syndrome who are treated with continuous positive airway pressure (CPAP).

Data collected included age at surgery, initial presentation, imaging characteristics prior to surgery, laterality of the fistula tract, pathology results and follow-up data.

Results: Twenty-eight patients met the criteria for inclusion. Three patients (11%) had bilateral fistulae. 11 (39%) were male and 17 (61%) were female. 23 (74.2%) tracts

Tariquidar ic50 were lined with ciliated columnar epithelium, 3 (9.7%) had cuboidal epithelium, and 5(16.7%) had squamous epithelium. Nineteen (61.3%) tracts contained salivary tissue. Of the unilateral fistula tracts, 25(100%) were on the right side. Of the 3 patients with bilateral lesions, 2 (66%) had associated branchio-oto-renal syndrome (BORS).

Conclusions: Second branchial cleft fistulae are rare. They are usually right-sided. If bilateral fistulae are present, one should consider an underlying genetic disorder. The histology of the fistulae mostly demonstrates ciliated columnar epithelium with the majority of specimens showing salivary tissue. There is a clear association with the internal jugular vein (IJV). Dissection should continue until superior to the hyoid bone, ensuring near complete surgical dissection

and less risk of recurrence. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and mortality and, given its association with age, the prevalence of CAVD is expected to continue to rise as global life expectancy increases. No drug strategies currently exist to https://www.selleckchem.com/products/ABT-737.html selleck inhibitor prevent or treat CAVD. Given that valve replacement is the only available clinical option, patients often cope with a deteriorating quality of life until diminished valve function demands intervention. The recognition that CAVD results from active cellular mechanisms suggests that the underlying pathways might

be targeted to treat the condition. However, no such therapeutic strategy has been successfully developed to date. One hope was that drugs already used to treat vascular complications might also improve CAVD outcomes, but the mechanisms of CAVD progression and the desired therapeutic outcomes are often different from those of vascular diseases. Therefore, we discuss the benchmarks that must be met by a CAVD treatment approach, and highlight advances in the understanding of CAVD mechanisms to identify potential novel therapeutic targets.”
“The aim of the present study was to evaluate phosphatidylserine translocation in specific patient groups and compare the rates of apoptosis between ejaculated and testicular spermatozoa. Fifty-six patients undergoing infertility treatments were included in the present study. Semen samples (n = 37) were obtained from cases with normozoospermia (it = 9) and abnormal semen parameters (n = 28). Testicular biopsy was performed in 19 patients, eight with obstructive and six with non-obstructive (hypospermatogenesis) azoospermia, and in five patients without azoospermia (anejaculation and oligozoospermia).

(C) 2010 European Society selleck chemicals for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.”
“Background: The intraaortic balloon pump (IABP) is the most commonly used mechanical circulatory support for patients with acute coronary syndromes and cardiogenic

shock. Nevertheless, IABP-related complications are still frequent and associated with a poor prognosis.

Hypothesis: To prospectively assess the incidence and predictors of complications in patients treated with IABP.

Methods: A total of 481 patients treated with IABP were prospectively enrolled in our registry (the Florence Registry). At multivariable logistic regression analysis the following variables were independent predictors for complications (when adjusted for age > 75 years, eGFR and time length of IABP support): use of inotropes (OR 2.450, P < 0.017), nadir platelet count (1000/mu L step; OR 0.990, P < 0.001), admission lactate (OR 1.175, P = 0.003). Nadir platelet count showed a negative correlation with length of time of IABP implantation (r – 0.31; P < 0.001). A nadir platelet count cutoff value of less than 120,000 was identified using a receiver operating characteristic (ROC) curve for the development of complications (area under the curve [ AUC] 0.70; P < 0.001).

Results: Complications were observed

in the 13.1%, among whom 33 of 63 showed major bleeding. The incidence of complications was higher in patients aged > 75 years (P = 0.015) and in those who had an IABP implanted for more than 24 hours (P = 0.001). Eltanexor supplier Patients with complications showed an in Intensive Cardiac Care Unit (ICCU) mortality higher than patients who did not (44.4% vs 17.2%, P < 0.001).

Conclusions: In consecutive patients treated with IABP support, the degree of hemodynamic impairment and the decrease in platelet count were independent predictors KU-60019 in vivo of complications, whose development was associated with higher in-ICCU mortality.”
“Background:

Metabolic Syndrome (MetSyn) is one of the strongest predictors of type 2 diabetes (DM2) and cardiovascular disease (CVD). It is associated with a 4- to 10-fold increased risk of DM2 and a 2- to 3-fold increased risk of CVD. Low income and minority women have some of the highest rates of MetSyn. This study examines the effect of a unique, community based, primary prevention program on the rates of MetSyn and health habits.

Methods: Sixty-four low income and minority women were enrolled in the HAPPY (Health Awareness and Primary Prevention in Your neighborhood) Heart Program in an eastern suburb of Boston. Over these 2 years, patients were evaluated by an interdisciplinary medical team: their primary physician, cardiologist, nutritionist, physical therapist, and health coach. The rate of MetSyn was measured at baseline, year 1, and year 2. Comparisons were made either using the paired t test for normally distributed variables or the Wilcoxon Sign test for non-normal variables.

Results: The rate of MetSyn fell from 64.

It greatly improved the oral bioavailability of flurbiprofen in rats. Thus, gelatin could be used as a carrier in the development of solid SMEDDS with improved oral bioavailability of poorly water-soluble drug.”
“OBJECTIVE: To estimate whether a gel containing the spermicide selleck chemicals llc C31G was noninferior

to a commercially available product containing nonoxynol-9.

METHODS: Participants were healthy, sexually active women aged 18-40 years. Measured outcomes included pregnancy rates, continuation rates, adverse events, and acceptability. The primary study outcome was contraceptive efficacy. Sample size was calculated at a 2.5% significance level using a one-sided test based on assumed 6-month pregnancy probability of 15% in the nonoxynol-9 group. Sample size was sufficient

to reject, with 80% power, the null hypothesis that pregnancy probability in the C31G arm would be more than 5% higher.

RESULTS: Nine hundred thirty-two women were randomized in the C31G group and 633 in the nonoxynol-9 group. For randomized patients with at least one episode of coitus (modified intent-to-treat group), 6-month pregnancy probabilities were 12.0% (95% confidence interval [CI] 9.3-14.7%) and 12.0% (95% CI 8.7-15.3%) for C31G and nonoxynol-9, respectively. Twelve-month pregnancy probabilities were 13.8% (95% CI 7.6-20%) for C31G and 19.8% (95% GSK461364 solubility dmso CI 10.9-28.7%) for nonoxynol-9. Two serious adverse events were deemed possibly related to study product and neither occurred in the C31G group. Three fourths of users in either group reported that they liked their assigned study product. Approximately 40% of patients discontinued prematurely for reasons other than pregnancy with 11% lost to follow-up.

CONCLUSION: C31G demonstrated noninferior contraceptive efficacy compared with nonoxynol-9. C31G may provide another marketable option for women seeking spermicidal contraception.”
“We present a novel algorithm to accelerate feature based registration, and demonstrate the utility of the algorithm for the alignment of large transmission electron microscopy (TEM)

images to create 3-D images of neural ultrastructure. In contrast to the most similar algorithms, which achieve GSK126 clinical trial small computation times by truncated search, our algorithm uses a novel randomized projection to accelerate feature comparison and to enable global search. Further, we demonstrate robust estimation of nonrigid transformations with a novel probabilistic correspondence framework, that enables large TEM images to be rapidly brought into alignment, removing characteristic distortions of the tissue fixation and imaging process. We analyze the impact of randomized projections upon correspondence detection, and upon transformation accuracy, and demonstrate that accuracy is maintained. We provide experimental results that demonstrate significant reduction in computation time and successful alignment of TEM images.

Concentrations of chemokines – MIP-1 alpha (CCL3), MIP-1 beta 1 (CCL4), RANTES (CCL5), GRO-alpha (CXCL1) and ENA-78 (CXCL5) – were measured by ELISA. Logistic regression was used to investigate regression relationships between the occurrence of neonatal chemokines concentrations in umbilical cord blood and mode and time of delivery. Results: Concentrations

of CXC chemokines in late-preterm neonates were the same as those in term neonates. RANTES concentrations in late-preterm cord blood were significantly lower than concentrations in term cord blood. Concentrations of the CC chemokine – RANTES (CCL5) – were noted to be lower in neonates born to cesarean section than in neonates born vaginally. Any anesthetic taken by the mothers during cesarean section did not affect CC chemokine production Selleckchem Entrectinib in the cord blood of full-term neonates. In a logistic regression model including selleck kinase inhibitor gestational age as a variable, late-preterm delivery was associated with RANTES concentrations (OR = 3.8). After adjustment for variable mode of delivery

in regression model, RANTES concentration (OR = 4.75). Conclusion: Both late-preterm and cesarean delivery are essential risk factors of low RANTES (CCL5) concentrations in the umbilical cord blood.”
“Increased waist circumference (WC) and related anthropometric indices have been shown to be, independently of body weight and body mass index (BMI), associated with adverse metabolic traits in many populations. selleck screening library It is unknown, however, whether WC also predicts adverse metabolic traits in severely obese subjects displaying a BMI greater than 35 kg/m(2). To address this question, we analyzed a dataset including 838 severely obese patients

(597 women, BMI 44.6 +/- 6.2 kg/m(2); 241 men, BMI 44.3 +/- 5.7 kg/m(2)). Body weight, height, WC, hip circumference, and blood pressure were measured in all subjects along with the following metabolic blood markers: fasting glucose, insulin, glycolized hemoglobin levels, triglycerides, total cholesterol, low- and high-density cholesterol, and uric acid. Multivariate regression analyses indicated that WC as well as related anthropometric indices, in particular those accounting for subjects’ height, were associated with many metabolic variables independently of body weight and BMI. In general, height-adjusted WC indices were more closely associated with metabolic traits in women than in men. Collectively, our findings suggest that body fat distribution also plays an important role in determining metabolic traits in severely obese subjects and that WC represents a valuable marker of abdominal/visceral obesity in this population.”
“A new labdanic norditerpene and six known labdanic diterpenes were isolated from the petroleum ether extract of the needles of Pinus sylvestris.

022) activities were reduced in patients with a more impaired endothelium-dependent vasodilation. Recently diagnosed treatment-naive essential hypertensives showed a relationship between the endothelial dysfunction, serum markers of inflammation and remodelling and levels of antioxidant substances. These could be potentially helpful markers of high risk in hypertensive patients. Journal of Human Hypertension

(2010) 24, 373-379; doi:10.1038/jhh.2009.91; published online 26 November 2009″
“The feasibility of using the conventional two-step procedure involving the thermal imidization of a high-molecular-weight poly(amic acid) (PAA) for the preparation of self-supporting polyimide (PI) films was studied. Synthesized Selleckchem JAK inhibitor PAA and PI were analyzed with respect to their molecular weights, chemical structures, and mechanical and thermal properties. The results showed that a high-molecular-weight PAA was successfully synthesized from 2,2-bis(3-amino-4-hydroxyphenyl)hexafluoropropane with 3,30,4,40-benzophenone tetracarboxylic dianhydride. The high intrinsic viscosity of PAA was 1.5 dL/g. Self-supporting PI films were successfully prepared by the thermal imidization of PAA and reached maximum tensile strength, tensile modulus, and elongation at break values of 103 MPa, 2.2 GPa, and 10.7%, respectively. The PI films were stable to 426-483

degrees C (the 5% weight loss temperature) and had a glass transition Selleck Dibutyryl-cAMP DZNeP solubility dmso at 271-283 degrees C. All these results indicate that the conventional two-step procedure involving thermal imidization is a promising method for

preparing self-supporting PI films with reasonable levels of mechanical and thermal properties. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 702-706, 2011″
“We investigate the bifurcation instabilities of swelling circular hydrogel plates programed with a space-varying cross-linking density along the radial direction. Depending on the distribution of the cross-linking density and the aspect ratio of the plate, different buckling patterns are observed. When the cross-linking density is lower at the center and increases monotonically outwards, a global buckling occurs, and the hydrogel plate forms an axisymmetric bowl-shaped container. When the cross-linking density is higher at the center and decreases monotonically outwards, edge wrinkling occurs. These wrinkles can be either localized near the edge or penetrate deep into the plate, depending on the detailed distribution of the cross-linking density. The rich post-buckling morphologies exhibited by the programed hydrogel plate provide a powerful route to fabricate smart hydrogel components, such as, self-adjusting containers and microlenses. (C) 2011 American Institute of Physics. [doi:10.1063/1.3565060]“
“Clinical and prognostic values of left ventricular concentric remodelling (LVCR) are based on definition of this cardiac phenotype according to outdated guidelines indications.

Methods: During urodynamics, bladder sensations were studied and compared in 59 patients: 21 patients with complete SCI below T6 and above Th12, 7 patients with a complete lesion of the conus medullaris, 11 patients with a complete lesion of the cauda equina, and 20 patients without neurological deficit. Results: Two of 7 patients with complete conus lesion had a

preserved filling sensation. Ten of 11 patients with complete Go 6983 supplier lesion of the cauda equina reported a bladder filling sensation. Sensations are perceived at a similar pressure threshold but at a higher volume threshold. Conclusions: In patients with a complete cauda or a lower conus lesion, a sensory input from the bladder is preserved. These findings imply that the preserved bladder filling sensation in complete cauda or lower conus lesions is possibly transferred through the intact hypogastric plexus to the thoracolumbar segments of the spinal cord. Copyright (c) 2012 S. Karger AG, Basel”
“Hf-rich hafnia-titania nanolaminate films with five HfO(2)-TiO(2) bilayer architectures (0.64 to 0.94 Hf atom fraction) were sputter deposited on unheated fused silica substrates, annealed post-deposition from 573 to 1273 K, and analyzed by x-ray diffraction to study phase selection and transition. Isochronal annealing for 1 h intervals from 573 to 1173

K produces weak crystallization into monoclinic (m) HfO(2) doped with Ti, i.e., m-Hf(1-x)Ti(x)O(2). The amount selleckchem of Ti incorporated into m-HfO(2) depends upon both architecture and overall stoichiometry, but in all but the coarsest architecture, CP-690550 exceeds the bulk solubility limit of x = 0.05. Initial annealing at 1273 K produces significant crystallization into a biphasic structure, m-Hf(1-x)Ti(x)O(2) and orthorhombic (o) HfTiO(4). From bulk phase equilibrium considerations, o-HfTiO(4) is expected to crystallize under conditions of interfacial bilayer mixing. However, upon further annealing at 1273 K, o-HfTiO(4) proves to be unstable. o-HfTiO(4) demixing inevitably

occurs independent of architecture and stoichiometry, resulting in final crystallization products after 96 h at 1273 K that are m-Hf(1-x)Ti(x)O(2) with x approximate to 0.05 and TiO(2) doped with Hf. We suggest that o-HfTiO(4) instability arises from a driving force to form domains similar to those found in the low temperature in/commensurate structures of ZrTiO(4). A detailed crystallographic group-subgroup analysis of the o (Pbcn) -> m (P2(1)/c) transition shows that these domains can be represented by an orientation twin in the latter structure and their creation can be achieved by a single step second-order phase transition. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3597321]“
“We included 3088 well-appearing infants aged between 3 and 36 months with fever without a source with a blood culture done as part of their study of fever.