4% versus 24.8%, P=0.012) but not for major cytogenetic responses (49.1% versus 44.2%, P=0.462). The rate of major molecular responses was also significantly better at 3 and 6 months

in the high-dose arm (month 3: 14.9% versus 3.5%, P=0.003; month 6: 32.5% versus 8.8%, P < 0.001). Overall and progression-free survival rates were comparable between arms, but event-free survival was significantly worse in the high-dose arm (P=0.014).\n\nConclusions\n\nStandard-dose imatinib remains the standard of care for pre-treated patients with chronic phase chronic myeloid leukemia (Clinicaltrials.gov identifier: NCT00327262).”
“Early-onset multiple sclerosis (EOMS) is defined as the first presentation of symptoms in childhood (before the age of 16 years). EOMS occurs in about 0.4% to 10.5% of multiple sclerosis (MS) patients.\n\nIn this retrospective population-based this website study we aimed to describe the clinical/paraclinical details and frequency of epileptic seizures in Iranian EOMS patients registered with the Isfahan Multiple Sclerosis Society (IMSS) from April 2003 to July 2010. EOMS cases were extracted from the Isfahan total MS cohort and included 3522 patients.\n\nA total of 117 EOMS patients (19 males and 98 females) with a mean age at onset of 14.2 +/- 2.0 years (range: 7-16 years) were extracted from our database (3.3% of the total cohort). Of cases, ten (one male and nine females) had experienced at least two epileptic seizures, providing a crude

prevalence of 8.5%. The frequency of epilepsy in EOMS patients (8.5%, 10/117) was significantly greater check details (P < 0.001) than that of non-EOMS cohort (2.0%, 71/3405). Epileptic seizures occurred before MS onset in two patients, after MS onset in seven, and at MS onset in one as the presenting symptom of the disease.\n\nOur findings mostly indicate an excessive prevalence of epileptic seizures in Iranian EOMS patients (8.5%), which is higher than any other report concerning seizures or epileptic seizures in a large MS series.”
“A detailed HSP990 clinical trial evaluation of the kinetics of domino free radical photopolymerization

(DFRP) based on phototriggered base proliferation reaction and redox initiation was described in the condition of eliminating the heat of polymerization via reacting in the thin polymer films. First, domino photoinitiating system made a substantial breakthrough in the photoefficiency of amine generation in contrast to photocaged base system, exhibiting marked improvement in the photosensitivity. Second, both the structural feature of base amplifier (BA) and reaction temperature as two important factors impacting the proliferation rate have been detailed. Third, different domino photoinitiating components, such as BAs, peroxides, and acrylates, were investigated in the thin polymer films. It is shown that both primary and secondary BAs are efficient catalysts for DFRP. Furthermore, polymerization rate shows a consistent dependence on the pK(a) value of the proliferated amine.