J Pathol 2000,191(3):239–244.PubMedCrossRef 31. Giri D, Ozen M, Ittmann M: Interleukin-6 is an autocrine growth factor in human prostate cancer. Am J Pathol 2001,159(6):2159–2165.PubMedCrossRef 32. Culig Z, Steiner H, Bartsch G, Hobisch A: Interleukin-6 regulation of prostate cancer cell growth. J Cell Biochem 2005,95(3):497–505.PubMedCrossRef

33. Hobisch A, Ramoner R, Fuchs D, Godoy-Tundidor S, Bartsch G, Klocker H, Culig Z: Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) DNA Damage inhibitor treatment express IL-6 and acquire an IL-6 partially resistant phenotype. Clin Cancer Res 2001,7(9):2941–2948.PubMed 34. Steiner H, Godoy-Tundidor S, Rogatsch H, Berger AP, Fuchs D, Comuzzi B, Bartsch G, Hobisch A, Culig Z: Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway. Am J Pathol 2003,162(2):655–663.PubMedCrossRef 35. Seaton A, Scullin P, Maxwell PJ, Wilson C, Pettigrew J, Gallagher R, O’Sullivan Tariquidar purchase JM, Johnston PG, Waugh DJ: Interleukin-8 signaling promotes androgen-independent

proliferation of prostate cancer cells via induction of androgen receptor expression and activation. Carcinogenesis 2008,29(6):1148–1156.PubMedCrossRef 36. Araki S, Omori Y, Lyn D, Singh RK, Meinbach DM, Sandman Y, Lokeshwar VB, Lokeshwar BL: Interleukin-8 Is a Molecular Determinant

of Androgen Independence and Progression in Prostate Cancer. Cancer Res 2007,67(14):6854–6862.PubMedCrossRef 37. Webster GF, Leyden JJ, Musson RA, Douglas SD: Susceptibility of Propionibacterium acnes to killing and degradation by human neutrophils and monocytes in vitro. Infect Immun 1985,49(1):116–121.PubMed 38. Good PI: Permutation tests: a practical guide to resampling methods for testing hypotheses. 2nd edition. New York: Springer; 2000. Authors’ contributions JBD carried out the tissue culture infections, the mRNA assays and the protein quantification. OA participated in the experimental design. PB performed the CX-6258 concentration statistical analysis. FE initiated the study and participated in its design. JO participated in the design of the study, performed pilot studies of experimental conditions and drafted the manuscript. All authors read and approved the final Linifanib (ABT-869) manuscript.”
“Background In most natural environments, microorganisms exist predominantly as biofilms rather than as free floating planktonic cells [1]. A biofilm can be defined as a complex functional community of one or more species of microbes encased in extra cellular polymeric substances and, attached to one another or to a solid surface [2]. Biofilms can be composed of a single microbial species or more commonly, mixed species such as bacteria and fungi [3, 4]. Perhaps the most studied example of the biofilm in humans is the dental plaque[5].