Data

Data IWP-2 datasheet represent means ± SEM, *p < 0.05; **p < 0.01; ***p < 0.001. (PDF 8 MB) Additional file 3: Figure S3: Survival of mice intragastrically inoculated with Lmo-EGD-lux or Lmo-InlA-mur-lux. Survival curves of female C57BL/6J, BALB/cJ, A/J OlaHsd, and C3HeB/FeJ mice inoculated intragastrically with 5 × 109 CFU Lmo-EGD-lux (A) or Lmo-InlA-mur-lux

(B). n = 10 for each mouse inbred and listerial strain. (PDF 955 KB) References 1. Barbuddhe SB, Chakraborty T: Listeria as an enteroinvasive gastrointestinal pathogen. Curr Top Microbiol Immunol 2009, 337:173–195.PubMedCrossRef 2. Swaminathan B, Gerner-Smidt P: The epidemiology of human listeriosis. Microb Infect 2007,9(10):1236–1243.CrossRef 3. Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M: Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin. J Exp Med 2011,208(11):2263–2277.PubMedCrossRef 4. Corr S, Hill C, Gahan CG: An in vitro cell-culture model demonstrates

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P: E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells. Cell 1996,84(6):923–932.PubMedCrossRef 10. Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E, Wehland J, Chakraborty T, Heinz DW: Structure of internalin, a major invasion protein of Listeria monocytogenes , in complex with its human receptor E-cadherin. Cell 2002,111(6):825–836.PubMedCrossRef 11. Lecuit M, Dramsi S, Gottardi C, Fedor-Chaiken M, Gumbiner B, Cossart P: A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes . EMBO J 1999,18(14):3956–3963.PubMedCrossRef 12. Wollert T, AZD4547 research buy Pasche B, Rochon M, Deppenmeier S, van den Heuvel J, Gruber AD, Heinz DW, Lengeling A, Schubert WD: Extending the host range of Listeria monocytogenes by rational protein design. Cell 2007,129(5):891–902.PubMedCrossRef 13.

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