The potential role of insulin biological effects, and particularly the possibility that insulin effects could be under modulation of adenosine receptors-activation

mediated cell signalling in the human fetal endothelium, could be a promising perspective for a potential therapeutic approach to be considered after appropriate population studies. This mechanism could help to improve insulin effectiveness in women coursing with GDM, having as a consequence a reduced alteration in the endothelial function in the human fetoplacental vasculature. The authors thank the personnel at the Hospital Clínico PLX4032 concentration Pontificia Universidad Católica de Chile labor ward for the support in placentas supply. The support from the following entities is acknowledged: Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT 1110977,

11110059, 3130583), Programa de Investigación Interdisciplinario (PIA) from Comisión Nacional de Investigación en Ciencia y Tecnología (CONICYT, Anillos ACT-73)-Chile and CONICYT Apoyo de Tesis (CONICYT AT-24120944). E Guzmán-Gutiérrez, T Sáez, and P Arroyo hold CONICYT-PhD (Chile) fellowships. P Arroyo and R Salsoso hold Faculty of Medicine, Pontificia Universidad Católica de Chile PhD fellowships. Enrique Guzmán-Gutiérrez: Dr Guzmán-Gutiérrez (medical technologists) selleckchem holds MSc in clinical biochemistry and Thymidylate synthase immunology, and a second MSc in biological sciences with mention in physiology sciences. He is PhD(c) in physiological sciences where he has developed his degree thesis on the potential beneficial effect of activation of adenosine receptors on the modulation of l-arginine transport by insulin in human placental endothelial cells from normal or gestational diabetes mellitus (GDM)

pregnancies. His research activities also involve the potential role of equilibrative nucleoside adenosine transporters expression and activity in the maturation of human endothelial progenitor cells. Pablo Arroyo: Dr Arroyo (MD) is a PhD(c) in medical sciences where he has developed his degree thesis on the alterations of brain development in a genetic animal model of GDM. His proposal is that GDM alters astrocyte function specifically in its ability to regulate extracellular adenosine levels by alterations in the uptake mechanisms of this nucleoside resulting in dysfunctional synapses formation. Rocío Salsoso: Miss Salsoso (pharmacists) is a PhD in Medical Sciences student at the Pontificia Universidad Católica de Chile. She is involved in the study of the mechanisms of human fetovascular reactivity and micro- and macrovascular endothelial function in response to l-carnitine and other amino acids in gestational diabetes. Bárbara Fuenzalida: Miss Fuenzalida is a last year biochemistry student at the Universidad de Antofagasta.