Unruptured epidermal cysts, correspondingly, are characterized by arborizing telangiectasia, whereas ruptured epidermal cysts present with peripheral, linear, branched vessels (45). The dermoscopic presentation of steatocystoma multiplex, similar to milia, typically includes a peripheral brown border, linear vascular patterns, and a homogeneous yellow coloration of the involved area, as reported in reference (5). It's noteworthy that, in contrast to the linear vessel structures observed in other cystic lesions, pilonidal cysts are marked by the presence of dotted, glomerular, and hairpin-shaped vessels. When evaluating pink nodular lesions, it is essential to include pilonidal cyst disease in the differential diagnosis alongside amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma (3). Common dermoscopic features observed in our cases and two previously documented instances of pilonidal cyst disease include a pink backdrop, central ulceration, peripherally arranged dotted vessels, and white linear markings. Pilonidal cyst disease is characterized, as demonstrated by our observations, by the presence of central yellowish, structureless regions, as well as peripheral hairpin and glomerular vessels within its dermoscopic presentation. In conclusion, dermoscopic features, as previously outlined, effectively separate pilonidal cysts from other skin lesions, thus aiding the diagnosis in patients where a pilonidal cyst is suspected clinically. Further investigation is required to more precisely define and quantify the usual dermoscopic characteristics of this illness and their prevalence.

Dear Editor, in the English medical literature, the uncommon condition of segmental Darier disease (DD) has been reported in about 40 instances. A potential cause of the disease, according to a hypothesis, is a post-zygotic somatic mutation in the calcium ATPase pump, localized to lesional skin tissue. DD type 1 segments exhibit lesions aligned with Blaschko's lines solely on one side of the body, contrasting with DD type 2, which manifests as concentrated areas of increased severity in patients with widespread DD (1). The difficulty in diagnosing type 1 segmental DD arises from the frequent absence of a positive family history, the disease's delayed appearance usually during the third or fourth decade, and the absence of characteristic features linked to DD. The differential diagnosis of type 1 segmental DD includes acquired papular dermatoses with linear or zosteriform distributions, such as lichen planus, psoriasis, lichen striatus, or linear porokeratosis (2). In this report, we present two cases of segmental DD, the first being a 43-year-old female who had suffered from pruritic skin alterations for five years, with symptoms worsening during specific seasons. During the examination, a swirling configuration of small, keratotic papules, ranging in color from light brownish to reddish, was found on the left abdomen and inframammary region (Figure 1a). A dermoscopic examination revealed yellowish-brown, polygonal or roundish areas, demarcated by a surrounding, whitish, featureless zone (Figure 1b). Lab Equipment The histopathological correlation between dermoscopic brownish polygonal or round areas and the presence of hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes in the biopsy specimen (Figure 1, c) is noteworthy. Figure 1, displaying panel d, demonstrates the considerable improvement achieved by the patient after being prescribed 0.1% tretinoin gel. In the second case, a 62-year-old female presented with a zosteriform rash on her right upper abdomen, consisting of small red-brown papules, eroded papules, and yellowish crusts (Figure 2a). A dermoscopic examination revealed polygonal, roundish, yellowish areas encircled by a structureless halo of whitish and reddish pigmentation (Figure 2b). Histopathology demonstrated a prominent pattern of compact orthokeratosis, interspersed with small areas of parakeratosis, a distinct granular layer showcasing dyskeratotic keratinocytes, and scattered foci of suprabasal acantholysis, all suggestive of DD (Figure 2, d, d). A prescription of topical steroid cream and 0.1% adapalene cream contributed to an enhancement in the patient's condition. In both of our subjects, the clinico-histopathologic concordance pointed towards a conclusive diagnosis of type 1 segmental DD; acantholytic dyskeratotic epidermal nevus, which is impossible to distinguish from segmental DD through histopathology alone, remained a potential diagnosis. The diagnosis of segmental DD was reinforced by the late manifestation and worsening of the condition due to external influences, such as heat, sunlight, and sweat. Clinico-histopathological assessment typically forms the basis for a conclusive type 1 segmental DD diagnosis; however, dermoscopy is instrumental in the diagnostic process by narrowing down the differential possibilities, recognizing their distinctive dermoscopic hallmarks.

Infrequently, condyloma acuminatum impacts the urethra, and when it does, the distal part is most often the location of the infection. Numerous therapies have been documented for the management of urethral condylomas. The treatments, including laser treatment, electrosurgery, cryotherapy, and topical cytotoxic agents such as 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod, are both extensive and variable in nature. The treatment of intraurethral condylomata is typically performed using laser therapy. This case study describes the effective treatment of meatal intraurethral warts in a 25-year-old male patient through the application of 5-FU, following unsuccessful therapies including laser treatment, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid.

Ichthyoses, a diverse collection of skin disorders, are recognized by their characteristic erythroderma and generalized scaling. The link between ichthyosis and melanoma has not been thoroughly explored. We detail a singular instance of acral melanoma of the palm, observed in an elderly patient concurrently diagnosed with congenital ichthyosis vulgaris. Melanoma with ulceration and a superficially spreading pattern was identified via the biopsy procedure. Within the scope of our present data, no acral melanomas have been reported in patients with congenital ichthyosis. Despite the presence of ichthyosis vulgaris, the potential for melanoma invasion and metastasis warrants routine clinical and dermatoscopic monitoring.

We present a case study of penile squamous cell carcinoma (SCC) in a 55-year-old male. free open access medical education A mass in the patient's penis displayed a pattern of progressive enlargement. To eliminate the mass, a partial penectomy was undertaken. The microscopic findings were consistent with a highly differentiated squamous cell carcinoma. Human papillomavirus (HPV) DNA's presence was confirmed through polymerase chain reaction analysis. HPV type 58 was discovered in a squamous cell carcinoma sample by means of sequencing analysis.

Genetic syndromes often showcase a combination of cutaneous and non-cutaneous abnormalities, a condition widely reported across medical studies. Although much is known, further syndromic patterns, as of yet unrecorded, could potentially exist. this website This case report highlights the admission of a patient to the Dermatology Department, whose multiple basal cell carcinomas were linked to a nevus sebaceous. Along with cutaneous malignancies, the patient displayed palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, a uterine myoma, an ovarian cyst, and a highly atypical colon adenoma. Multiple disorders occurring together might indicate a genetic etiology of the diseases.

Drug-induced vasculitis arises from drug exposure, initiating the inflammation of small blood vessels, ultimately damaging the affected tissue. Rare occurrences of vasculitis brought on by medication used in chemotherapy or chemoradiotherapy are highlighted in the medical literature. The medical evaluation of our patient led to a diagnosis of small cell lung cancer, stage IIIA (cT4N1M0). A rash and cutaneous vasculitis appeared on the patient's lower extremities, a consequence of the second cycle of carboplatin and etoposide (CE) chemotherapy, which occurred four weeks prior. Upon discontinuation of CE chemotherapy, methylprednisolone was administered for symptomatic treatment. The administration of the prescribed corticosteroid medication resulted in an improvement of the local manifestations. The patient's treatment plan, subsequent to chemo-radiotherapy completion, included four cycles of consolidation chemotherapy using cisplatin, amounting to a total of six chemotherapy cycles. The cutaneous vasculitis demonstrated further regression, as confirmed by a clinical examination. Elective radiotherapy to the brain was implemented subsequent to the completion of consolidation chemotherapy. Clinical observation of the patient was sustained until the disease resurfaced. Subsequent courses of chemotherapy were employed for the platinum-resistant disease. The patient's demise arrived seventeen months after the diagnosis of SCLC. To our knowledge, this is the initial documented instance of a patient experiencing vasculitis in their lower limbs concurrent with radiotherapy and CE chemotherapy administered as part of the initial treatment protocol for SCLC.

In the professional fields of dentistry, printing, and fiberglass work, allergic contact dermatitis (ACD) from (meth)acrylates is a historically recognized occupational concern. Reports of complications associated with artificial nails have surfaced, impacting both those who apply them and those who receive them. The issue of ACD, triggered by (meth)acrylates in the manufacture of artificial nails, demands attention from both nail technicians and consumers. A 34-year-old woman, after working for two years in a nail art salon, encountered severe hand dermatitis, particularly on her fingertips, combined with recurrent facial dermatitis. The patient's nails, prone to splitting, necessitated the use of artificial nails for the past four months, complemented by regular gel applications for reinforcement. Her asthma manifested in several episodes while she was working at her workplace. A patch test was employed to assess the baseline series, acrylate series, and the patient's own material.